Results 261 to 270 of about 1,047,623 (298)
Some of the next articles are maybe not open access.
2003
Flavoproteins are ubiquitous proteins involved in diverse biological processes ranging from redox catalysis and light emission to DNA repair (1). Based on their function, flavoproteins can be divided into several subclasses including electron transferases, photolyases, synthases, dehydrogenases, disulfide reductases, oxidases, and monooxygenases.
van Berkel, W.J.H. +3 more
openaire +2 more sources
Flavoproteins are ubiquitous proteins involved in diverse biological processes ranging from redox catalysis and light emission to DNA repair (1). Based on their function, flavoproteins can be divided into several subclasses including electron transferases, photolyases, synthases, dehydrogenases, disulfide reductases, oxidases, and monooxygenases.
van Berkel, W.J.H. +3 more
openaire +2 more sources
Biophysics of Structure and Mechanism, 1980
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
openaire +2 more sources
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
openaire +2 more sources
Clinical Pharmacology and Therapeutics, 1982
Captopril, an angiotensin-converting enzyme inhibitor with antihypertensive properties, was given by mouth and intravenously in 10-mg doses to five healthy subjects. After intravenous dosing, semilogarithmic plots of captopril blood levels : time showed a triexponential decay. Data were analyzed using an open three-compartment model. The average volume
K L, Duchin +4 more
openaire +2 more sources
Captopril, an angiotensin-converting enzyme inhibitor with antihypertensive properties, was given by mouth and intravenously in 10-mg doses to five healthy subjects. After intravenous dosing, semilogarithmic plots of captopril blood levels : time showed a triexponential decay. Data were analyzed using an open three-compartment model. The average volume
K L, Duchin +4 more
openaire +2 more sources
Clinical Pharmacology & Therapeutics, 1978
The kinetics of protriptyline were examined in 8 subjects after a single oral dose of 30 mg protriptyline hydrochloride. Peak protriptyline levels ranged from 10.4 to 22.3 ng/ml and were reached 6 to 12 hr after the oral dose. The mean protriptyline half‐life (t½) was 74.3 hr and ranged from 53.6 to 91.7 hr in individual subjects, confirming the long ...
V E, Ziegler +6 more
openaire +2 more sources
The kinetics of protriptyline were examined in 8 subjects after a single oral dose of 30 mg protriptyline hydrochloride. Peak protriptyline levels ranged from 10.4 to 22.3 ng/ml and were reached 6 to 12 hr after the oral dose. The mean protriptyline half‐life (t½) was 74.3 hr and ranged from 53.6 to 91.7 hr in individual subjects, confirming the long ...
V E, Ziegler +6 more
openaire +2 more sources
Clinical Pharmacology and Therapeutics, 1981
Pharmacologic studies of the semisynthetic cephalosporin ceforanide were conducted in 29 cancer patients. Intravenous doses of 500 mg over 30 min every 6 hr to 10 patients induced mean peak serum concentrations between 44.7 and 51.5 micrograms/ml, while in 10 patients receiving 1 gm over 30 min every 12 hr mean peak serum concentrations varied from 73 ...
E H, Estey +5 more
openaire +2 more sources
Pharmacologic studies of the semisynthetic cephalosporin ceforanide were conducted in 29 cancer patients. Intravenous doses of 500 mg over 30 min every 6 hr to 10 patients induced mean peak serum concentrations between 44.7 and 51.5 micrograms/ml, while in 10 patients receiving 1 gm over 30 min every 12 hr mean peak serum concentrations varied from 73 ...
E H, Estey +5 more
openaire +2 more sources
Clinical Pharmacology and Therapeutics, 1983
Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4, and 6 mg. The plasma concentration-time data could be fitted to a zero-order absorption one-compartment open model. The elimination rate constant averaged 0.27 +/- 0.05 hr-1 (SD). The plasma AUC was linearly related to the dose.
H, Ehrsson +3 more
openaire +2 more sources
Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4, and 6 mg. The plasma concentration-time data could be fitted to a zero-order absorption one-compartment open model. The elimination rate constant averaged 0.27 +/- 0.05 hr-1 (SD). The plasma AUC was linearly related to the dose.
H, Ehrsson +3 more
openaire +2 more sources
Clinical Pharmacology and Therapeutics, 1984
The kinetics of tolrestat, a potent inhibitor of aldose reductase, were examined. Serum concentrations of tolrestat and of total 14C were measured after dosing normal subjects and subjects with diabetes with 14C-labeled tolrestat. In normal subjects, tolrestat was rapidly absorbed and disappearance from serum was biphasic.
D R, Hicks +5 more
openaire +2 more sources
The kinetics of tolrestat, a potent inhibitor of aldose reductase, were examined. Serum concentrations of tolrestat and of total 14C were measured after dosing normal subjects and subjects with diabetes with 14C-labeled tolrestat. In normal subjects, tolrestat was rapidly absorbed and disappearance from serum was biphasic.
D R, Hicks +5 more
openaire +2 more sources
1998
Throughout much of this book we have emphasized the description of a system in terms of an equilibrium state. This approach is invaluable when we are beginning study and are not sure exactly what are the elements and the linkages that comprise the rules of the system under study. Still it seems to be a compulsive pulse taking that is stodgy.
openaire +1 more source
Throughout much of this book we have emphasized the description of a system in terms of an equilibrium state. This approach is invaluable when we are beginning study and are not sure exactly what are the elements and the linkages that comprise the rules of the system under study. Still it seems to be a compulsive pulse taking that is stodgy.
openaire +1 more source
Clinical Pharmacology & Therapeutics, 1978
A spectrophotometric assay for measuring allopurinol and oxipurinol has been developed which can detect as little as 5 × 10−8 M of each in serum and urine. With this assay, serum disappearance characteristics of intravenous and orally administered allopurinol have been investigated in man.
K, Hande, E, Reed, B, Chabner
openaire +2 more sources
A spectrophotometric assay for measuring allopurinol and oxipurinol has been developed which can detect as little as 5 × 10−8 M of each in serum and urine. With this assay, serum disappearance characteristics of intravenous and orally administered allopurinol have been investigated in man.
K, Hande, E, Reed, B, Chabner
openaire +2 more sources
Clinical Oncology, 2007
Cell kinetic concepts have pervaded radiation therapy since the early part of the 20th century and have been instrumental in the development of modern radiotherapy. In this review, the fundamental radiobiological concepts that have been developed based on cell kinetic knowledge will be revisited and discussed in the context of contemporary radiation ...
openaire +2 more sources
Cell kinetic concepts have pervaded radiation therapy since the early part of the 20th century and have been instrumental in the development of modern radiotherapy. In this review, the fundamental radiobiological concepts that have been developed based on cell kinetic knowledge will be revisited and discussed in the context of contemporary radiation ...
openaire +2 more sources