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Trends in Plant Science, 2000
Kinetochores are large protein complexes that bind to centromeres. By interacting with microtubules and their associated motor proteins, kinetochores both generate and regulate chromosome movement. Kinetochores also function in the spindle checkpoint; a surveillance mechanism that ensures that metaphase is complete before anaphase begins.
Hong-Guo Yu +3 more
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Kinetochores are large protein complexes that bind to centromeres. By interacting with microtubules and their associated motor proteins, kinetochores both generate and regulate chromosome movement. Kinetochores also function in the spindle checkpoint; a surveillance mechanism that ensures that metaphase is complete before anaphase begins.
Hong-Guo Yu +3 more
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Journal of Cell Science, 2023
ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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Cullin' PLK1 from kinetochores
Nature Cell Biology, 2013To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3-KLHL22 is now identified as a critical step in promoting the release of PLK1 from ...
Colleen A, McGourty, Michael, Rape
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Kinetochore structure and function
Trends in Cell Biology, 2005The vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation. Kinetochores are assembled on centromeric chromatin through complex pathways that are coordinated with the cell cycle.
Gordon K, Chan +2 more
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Biochemical Society Transactions, 2006
The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic ...
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The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic ...
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Centromere and kinetochore structure
Current Biology, 1992Recent studies have begun to yield some insight into the structural and regulatory components of centromeres, and new assays have been developed that promise to be of use in advancing our understanding of centromere structure and function. In the budding yeast Saccharomyces cerevisiae new proteins that are required for centromere function have been ...
W C, Earnshaw, J E, Tomkiel
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Nature Cell Biology, 2003
The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint regulation is a recent example, raising the question of why such divergent processes as mitosis and nuclear transport use common proteins.
P. Todd Stukenberg, Ian G. Macara
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The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint regulation is a recent example, raising the question of why such divergent processes as mitosis and nuclear transport use common proteins.
P. Todd Stukenberg, Ian G. Macara
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Evolving Centromeres and Kinetochores
2017The genetic material, contained on chromosomes, is often described as the "blueprint for life." During nuclear division, the chromosomes are pulled into each of the two daughter nuclei by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin.
Steven, Friedman, Michael, Freitag
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Kinetochore Malfunction in Human Pathologies
2017The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error ...
de Wolf, Bas, Kops, Geert J.P.L.
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