Results 181 to 190 of about 507,315 (267)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Management of HER2+ Breast Cancer with and without Brain Metastases in Saudi Arabia: Literature Insights and an Expert Survey of Current Practices. [PDF]

Breast Cancer (Dove Med Press)
Kullab S, Refae A, Altwairgi A, Abusanad A, Elsamany S, Abdelhafiez NA, Basulaiman B, Zahralliyali A, Alshangiti AA, Al-Mubarak M, Alwbari A, Alharbi A, Osman A, Kiwan H, Alaklabi S.   +14 more
europepmc   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Postoperative Pain Outcomes and Satisfaction in Preschool Versus School-Age Children: A Prospective Multicenter Observational Study. [PDF]

Cureus
El-Tallawy SN, Pergolizzi JV, Alsubaie AT, Hegab MM, Haq AU, Abd El-Rahman AM, Helmy ML, Khan RA, Maghrabi HH, Rasheed AR, Helal DA, Tawfik AM, Elzakaziki SS, Alharbi MM, Mohyeldin AA, Delvi BM.   +15 more
europepmc   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

Book Reviews, Part 1

Scottish Studies, 1972
M. MacLeod R. D. S. Jack
doaj  

Successful Multidisciplinary Management of Esophageal Perforation Complicated by Septic Shock: A Race Against Time. [PDF]

Am J Case Rep
Sewify K, Alshamrani AS, Zakary N, Regal M, Elhassan A, Alsaher A, Gomaa W, Abdelshafey EE.   +7 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Evolution of the Healthcare System in Saudi Arabia Over the Last Century: A Historical and Policy Analysis. [PDF]

J Healthc Leadersh
Sheerah HA, Alzaaqi SM, Arafa A, Banjar WM, Liu K, Withers M, El-Jardali F, Penttinen P, Al-Jedai AH, Selbie D.   +9 more
europepmc   +1 more source