Results 1 to 10 of about 997 (102)

EAST/SeSAME Syndrome and Beyond: The Spectrum of Kir4.1- and Kir5.1-Associated Channelopathies [PDF]

Frontiers in Physiology, 2022
In 2009, two groups independently linked human mutations in the inwardly rectifying K+ channel Kir4.1 (gene name KCNJ10) to a syndrome affecting the central nervous system (CNS), hearing, and renal tubular salt reabsorption.
Jacky Lo, Anna-Lena Forst, Richard Warth, Anselm A. Zdebik, Anselm A. Zdebik   +4 more
doaj   +5 more sources

Diverse functions of the inward-rectifying potassium channel Kir5.1 and its relationship with human diseases [PDF]

Frontiers in Physiology, 2023
The inward-rectifying potassium channel subunit Kir5.1, encoded by Kcnj16, can form functional heteromeric channels (Kir4.1/5.1 and Kir4.2/5.1) with Kir4.1 (encoded by Kcnj10) or Kir4.2 (encoded by Kcnj15).
Chaojie Zhang, Chaojie Zhang, Chaojie Zhang, Chaojie Zhang, Jia Guo, Jia Guo, Jia Guo, Jia Guo   +7 more
doaj   +2 more sources

The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet [PDF]

Frontiers in Physiology, 2022
Basolateral potassium channels in the distal convoluted tubule (DCT) are composed of inwardly-rectifying potassium channel 4.1 (Kir4.1) and Kir5.1. Kir4.1 interacts with Kir5.1 to form a 40 pS K+ channel which is the only type K+ channel expressed in the
Xin-Xin Meng, Hao Zhang, Gui-Lin Meng, Shao-Peng Jiang, Xin-Peng Duan, Wen-Hui Wang, Ming-Xiao Wang   +6 more
doaj   +2 more sources

Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter [PDF]

JCI Insight, 2023
We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the basolateral inwardly rectifying potassium channel Kir4.1/Kir5.1 in the distal convoluted tubule (DCT). Application of tacrolimus (FK506) or cyclosporine A (CsA) increased whole-
Dan-Dan Zhang, Xin-Peng Duan, Kerim Mutig, Franziska Rausch, Yu Xiao, Jun-Ya Zheng, Dao-Hong Lin, Wen-Hui Wang   +7 more
doaj   +2 more sources

Targeting the inward rectifier potassium channel 5.1 in thyroid cancer: artificial intelligence-facilitated molecular docking for drug discovery [PDF]

BMC Endocrine Disorders, 2023
Background Recurrent and metastatic thyroid cancer is more invasive and can transform to dedifferentiated thyroid cancer, thus leading to a severe decline in the 10-year survival. The thyroid-stimulating hormone receptor (TSHR) plays an important role in
Xue Yang, Yonglin Wu, Shaojie Xu, Hanning Li, Chengcheng Peng, Xiaoqing Cui, Deenraj Kush Dhoomun, Ge Wang, Tao Xu, Menglu Dong, Xingrui Li, Yaying Du   +11 more
doaj   +2 more sources

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor [PDF]

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +2 more sources

Kir5.1-modulated potassium flux stimulates an anabolic kidney phenotype [PDF]

iScience
Summary: The kidney maintains systemic potassium (K+) balance through energy-intensive epithelial transport processes. Under K+-restricted conditions, kidney epithelial cells proliferate to accommodate profound increases in transport.
Aihua Wu, Masa-Ki Inoue, Yahua Zhang, Clinton M. Hasenour, Juan Pablo Arroyo, Fabian Bock, Alina Yu, Mohammed Z. Ferdaus, Yvette Blackwell, Roman M. Lazarenko, Jamey D. Young, Jerod S. Denton, Eric Delpire, Ming-Zhi Zhang, Raymond C. Harris, Andrew S. Terker   +15 more
doaj   +2 more sources

Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis [PDF]

Physiological Reports, 2021
The nitric oxide (NO)‐generating enzyme, NO synthase‐1β (NOS1β), is essential for sodium (Na+) homeostasis and blood pressure control. We previously showed that collecting duct principal cell NOS1β is critical for inhibition of the epithelial sodium ...
Kelly A. Hyndman, Elena Isaeva, Oleg Palygin, Luciano D. Mendoza, Aylin R. Rodan, Alexander Staruschenko, Jennifer S. Pollock   +6 more
doaj   +2 more sources

KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment [PDF]

Stem Cell Research & Therapy
Background The KCNJ16 gene has been associated with a novel kidney tubulopathy phenotype, viz. disturbed acid–base homeostasis, hypokalemia and altered renal salt transport.
E. Sendino Garví, G. J. J. van Slobbe, E. A. Zaal, J. H. F. de Baaij, J. G. Hoenderop, R. Masereeuw, M. J. Janssen, A. M. van Genderen   +7 more
doaj   +2 more sources

The physiological characteristics of inward rectifying potassium channel Kir4.2 and its research progress in human diseases [PDF]

Frontiers in Cell and Developmental Biology
Kir4.2 is a member of the inward rectifying potassium channel family, encoded by the KCNJ15 gene. The Kir4.2 protein is expressed in various organs including the kidneys, liver, pancreas, bladder, stomach, and lungs.
Hongling Zhang, Zhongyuan Bai, Yanfeng Xi, Yanfeng Xi   +3 more
doaj   +2 more sources