Results 141 to 149 of about 1,066 (149)

Modulation of the heteromeric Kir4.1–Kir5.1 channels by P at physiological levels

Journal of Cellular Physiology, 2001
AbstractSeveral inward rectifier K+ (Kir) channels are pH‐sensitive, making them potential candidates for CO2 chemoreception in cells. However, there is no evidence showing that Kir channels change their activity at near physiological level of P, as most previous studies were done using high concentrations of CO2.
N. Cui, L.R. Giwa, H. Xu, A. Rojas, L. Abdulkadir, C. Jiang   +5 more
openaire   +1 more source

Molecular Insights into the Possible Role of Kir4.1 and Kir5.1 in Thyroid Hormone Biosynthesis

Hormone Research in Paediatrics, 2015
<b><i>Introduction:</i></b> Thyroid morphogenesis is a complex process. Inwardly rectifying potassium (Kir) genes play a role in hormone release, cell excitability, pH and K⁺ homeostasis in many tissues. <b><i>Objectives:</i></b> To investigate the thyroid developmental expression ...
Helton Estrela, Ramos, Magnus Régios Dias, da Silva, Aurore, Carré, Joaquim Custódio, Silva, Rolf Matias, Paninka, Taise Lima, Oliveira, Elodie, Tron, Mireille, Castanet, Michel, Polak   +8 more
openaire   +2 more sources

Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels

Pflügers Archiv - European Journal of Physiology
Kir4.1/Kir5.1 channels play a crucial role in important physiological functions, notably in the kidneys and brain. A hallmark of these channels is the coexistence of two mechanisms of inward rectification: the classical "extrinsic" inward rectification induced by polyamines and Mg2+ blocking the pore, and a novel "intrinsic" voltage-dependent mechanism
Iván A. Aréchiga-Figueroa, Leticia G. Marmolejo-Murillo, Mayra Delgado-Ramírez, Rodrigo Zamora-Cárdenas, Eloy G. Moreno-Galindo, Tania Ferrer, Ricardo A. Navarro-Polanco, José A. Sánchez-Chapula, Aldo A. Rodríguez-Menchaca   +8 more
openaire   +2 more sources

[The function and regulation of basolateral Kir4.1 and Kir4.1/Kir5.1 in renal tubules].

Sheng li xue bao : [Acta physiologica Sinica], 2019
Basolateral inwardly-rectifying K+ channels (Kir) play an important role in the control of resting membrane potential and transepithelial voltage, thereby modulating water and electrolyte transport in the distal part of nephron. Kir4.1 and Kir4.1/Kir5.1 heterotetramer are abundantly expressed in the basolateral membrane of late thick ascending limb ...
Yu, Xiao, Xin-Xin, Meng, Hao, Zhang, Xi-Wen, Guo, Rui-Min, Gu   +4 more
openaire   +1 more source

Discovery and Characterization of VU0493206, the First Small-Molecule Activator of Kir4.1/Kir5.1 Channels

Journal of the American Society of Nephrology, 2022
Samantha J. Mcclenahan, Elena Isaeva, Christine A. Klemens, Alexander Staruschenko, Jerod S. Denton   +4 more
openaire   +1 more source

Kir5.1 Inwardly Rectifying Potassium Channel

2007
openaire   +1 more source

Kir5.1 Is Essential to Formation of Kir4.2/Kir5.1 Heterotetramer in the Basolateral Membrane of Mouse Proximal Tubules

Journal of the American Society of Nephrology
openaire   +1 more source

Functional consequences in ventilatory control of Kir5.1 mutation in rats

2016
openaire   +1 more source

Differential pH-sensitivity of Kir4.1 and Kir4.2 and modulation by heteropolymerisation with Kir5.1

2001
PESSIA, Mauro, IMBRICI P., D'ADAMO, Maria Cristina, SALVATORE L., TUCKER S. J.   +4 more
openaire   +2 more sources