Results 11 to 20 of about 1,066 (149)

Characterization of a novel variant in KCNJ16, encoding Kir5.1 channel [PDF]

Physiological Reports
The essential role of the inwardly rectifying potassium channel Kir5.1 (KCNJ16) in controlling electrolyte homeostasis and blood pressure has been demonstrated in human and animal studies.
Biyang Xu, Vladislav Levchenko, Ruslan Bohovyk, Ameneh Ahrari, Aron M. Geurts, Valerie Sency, Baozhong Xin, Heng Wang, Alexander Staruschenko   +8 more
doaj   +3 more sources

Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa. [PDF]

Int J Mol Sci, 2021
The ability of spermatozoa to swim towards an oocyte and fertilize it depends on precise K+ permeability changes. Kir5.1 is an inwardly-rectifying potassium (Kir) channel with high sensitivity to intracellular H+ (pHi) and extracellular K+ concentration [
Poli G, Hasan S, Belia S, Cenciarini M, Tucker SJ, Imbrici P, Shehab S, Pessia M, Brancorsini S, D'Adamo MC.   +9 more
europepmc   +7 more sources

Oxidative Stress Suppresses The Heteromeric Kir4.1-Kir5.1 Channel Via S-Glutathionylation [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Potassium transport channels regulate cellular excitability and membrane potentials. Dysfunction of potassium channels may happen under certain pathophysiological conditions via post-translational modification (PTM), inducing the S-glutathionylation, in ...
Wu, Yang
core   +18 more sources

KIR Channels in CO2 Central Chemoreception: Analysis with a Functional Genomics Approach [PDF]

The Journal of Physiology, 2007
The process of respiration is a pattern of spontaneity and automatic motor control that originate in the brainstem. The mechanism by which the brainstem detects CO2 is termed central CO2 chemoreception (CCR).
Rojas, Asheebo
core   +8 more sources

Deletion of Kcnj16 altered transcriptomic and metabolomic profiles of Dahl salt-sensitive rats [PDF]

iScience
Summary: The inwardly rectifying K+ channel Kir5.1 (Kcnj16) is essential in renal salt handling and blood pressure control. However, the underlying mechanisms are not fully understood.
Biyang Xu, Lashodya V. Dissanayake, Vladislav Levchenko, Adrian Zietara, Olha Kravtsova, Alexander Staruschenko   +5 more
doaj   +2 more sources

Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron. [PDF]

American Journal of Physiology-Renal Physiology, 2018
Kir4.1/5.1 heterotetramer participates in generating the negative cell membrane potential in distal convoluted tubule (DCT) and plays a critical role in determining the activity of Na-Cl cotransporter (NCC).
Gao, Z.X., Lin, D.H., Staub, O., Su, X.T., Wang, M.X., Wang, W.H., Wu, P.   +6 more
core   +4 more sources

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels [PDF]

European Biophysics Journal, 2008
Comparison of the crystal structures of the KcsA and MthK potassium channels suggests that the process of opening a K(+) channel involves pivoted bending of the inner pore-lining helices at a highly conserved glycine residue.
Lijun Shang, Stephen J. Tucker, S Berneche, D Bichet, JN Bright, M Casamassima, JF Cordero-Morales, N Cui, C Derst, S Ding, DA Doyle, DA Doyle, B Fakler, Y Jiang, T Jin, AA Konstas, A Kuo, MK Lancaster, SB Long, Z Lu, E Magidovich, E Perozo, M Pessia, M Pessia, P Proks, M Rapedius, A Rosenhouse-Dantsker, G Seebohm, L Shang, SJ Tucker, J Wu, Z Yang, Y Zhao   +32 more
core   +5 more sources

Novel KCNJ16 variants identified in a Chinese patient with hypokalemic metabolic acidosis. [PDF]

Mol Genet Genomic Med, 2023
Our study expands the variant spectrum of KCNJ16, enriches the clinical characteristics of HKTD, and provides a solid base for the genetic counseling, diagnosis and treatment of this condition. Abstract Background Biallelic pathogenic variants in the KCNJ16 gene result in hypokalemic tubulopathy and deafness (HKTD) (MIM #619406), which is a rare ...
Chen J, Fu Y, Sun Y, Zhou X, Wang Q, Li C, Yuan H.   +6 more
europepmc   +2 more sources

Kir5.1 channels: potential role in epilepsy and seizure disorders.

Am J Physiol Cell Physiol, 2022
Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the KCNJ16 gene) have not been fully recognized. This review focuses on the recent advances in understanding the expression
Staruschenko A, Hodges MR, Palygin O.
europepmc   +3 more sources

Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Genes and Diseases, 2021
Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang, Jian Han, Lingfei Li, Qiong Zhang, Yanhai Feng, Youzhao Jiang, Fang Deng, Yuping Zhang, Qinan Wu, Bing Chen, Jiongyu Hu   +10 more
doaj   +1 more source