Results 21 to 30 of about 1,066 (149)
Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation. [PDF]
AndrologyAbstract Background Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).
Delgado-Bermúdez A +3 more
europepmc +2 more sources
Deletion of Kcnj16 in Mice Does Not Alter Auditory Function
Frontiers in Cell and Developmental Biology, 2021 Endolymphatic potential (EP) is the main driving force behind the sensory transduction of hearing, and K+ is the main charge carrier. Kir5.1 is a K+ transporter that plays a significant role in maintaining EP homeostasis, but the expression pattern and ...
Jun Lv +19 more
doaj +1 more source
Relationship between the renin–angiotensin–aldosterone system and renal Kir5.1 channels [PDF]
Clinical Science, 2019 Abstract Kir5.1 (encoded by the Kcnj16 gene) is an inwardly rectifying K+ (Kir) channel highly expressed in the aldosterone-sensitive distal nephron of the kidney, where it forms a functional channel with Kir4.1. Kir4.1/Kir5.1 channels are responsible for setting the transepithelial voltage in the distal nephron and collecting ducts and ...
Anna D. Manis +5 more
openaire +2 more sources
Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits [PDF]
FEBS Letters, 2001 We have identified several cDNAs for the human Kir5.1 subunit of inwardly rectifying K+ channels. Alternative splicing of exon 3 and the usage of two alternative polyadenylation sites contribute to cDNA diversity. The hKir5.1 gene KCNJ16 is assigned to chromosomal region 17q23.1–24.2, and is separated by only 34 kb from the hKir2.1 gene (KCNJ2). In the
Derst, Christian +9 more
openaire +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +72 more
wiley +1 more source
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity
The Journal of Physiology, Volume 601, Issue 16, Page 3667-3686, 15 August 2023., 2023 Abstract figure legend Astrocytic NBCe1 expression is not required for CO2‐stimuated breathing in mice. Mice bearing ‘floxed’ alleles for Slc4a4, the gene that encodes the NBCe1 electrogenic Na+‐HCO3‐ co‐transporter, were crossed with two different lines of mice that express Cre recombinase preferentially in astrocytes.
Keyong Li +9 more
wiley +1 more source
mTOR signaling in renal ion transport
Acta Physiologica, Volume 238, Issue 1, May 2023., 2023 Abstract The mammalian target of rapamycin (mTOR) signaling pathway is crucial in maintaining cell growth and metabolism. The mTOR protein kinase constitutes the catalytic subunit of two multimeric protein complexes called mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).
Anastasia Adella, Jeroen H. F. de Baaij
wiley +1 more source
Journal of Internal Medicine, Volume 293, Issue 1, Page 4-22, January 2023., 2023 Abstract The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying ...
Nahid Tabibzadeh, Gilles Crambert
wiley +1 more source
Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat
JCI Insight, 2021 Kir5.1 is an inwardly rectifying potassium (Kir) channel subunit abundantly expressed in the kidney and brain. We previously established the physiologic consequences of a Kcnj16 (gene encoding Kir5.1) knockout in the Dahl salt-sensitive rat (SSKcnj16–/–),
Anna D. Manis +7 more
doaj +1 more source
The magic of MAGI‐1: A scaffolding protein with multi signalosomes and functional plasticity
Biology of the Cell, Volume 114, Issue 7, Page 185-198, July 2022., 2022 Summary of published MAGI‐1 functions Abstract MAGI‐1 is a critical cellular scaffolding protein with over 110 different cellular and microbial protein interactors. Since the discovery of MAGI‐1 in 1997, MAGI‐1 has been implicated in diverse cellular functions such as polarity, cell–cell communication, neurological processes, kidney function, and a ...
Katherine J. D. A. Excoffon +3 more
wiley +1 more source