Results 31 to 40 of about 1,066 (149)
Glia, Volume 70, Issue 4, Page 748-767, April 2022., 2022 Main Points Kir4.1 protein expression locally increases in astrocytes of an Alzheimer's disease mouse model with a higher density in the proximity of plaques. Astrocytes exposed to Aβ pathology maintain the ability to buffer K+ through functional Kir4.1 channels. Abstract Alzheimer pathology is accompanied by astrogliosis.
Christiaan F. M. Huffels +6 more
wiley +1 more source
Biochemical and Biophysical Research Communications, 2009 The inwardly-rectifying potassium channel subunit Kir5.1 selectively co-assembles with members of the Kir4.0 subfamily to form novel pH-sensitive heteromeric channels with unique single channel properties. In this study, we have cloned orthologs of Kir4.1 and Kir5.1 from the genome of the amphibian, Xenopus tropicalis (Xt).
Shang, L, Ranson, S, Tucker, S
openaire +3 more sources
Does the early aldosterone‐induced SGK1 play a role in early Kaliuresis?
Physiological Reports, Volume 10, Issue 4, February 2022., 2022 Does the Early Aldosterone‐Induced SGK1 Play a Role in Early Kaliuresis? Abstract Urinary K+ potassium excretion rapidly increases after a potassium‐rich meal. The early aldosterone‐induced sgk1 gene (encoding serum and glucocorticoid‐induced kinase 1), activates potassium clearance, but the role of this kinase in the early activation of K+ secretion ...
Lama Al‐Qusairi +4 more
wiley +1 more source
Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule
American Journal of Physiology-Renal Physiology, 2020 Cytochrome P-450 (Cyp) epoxygenase-dependent metabolites of arachidonic acid (AA) have been shown to inhibit renal Na+transport, and inhibition of Cyp-epoxygenase is associated with salt-sensitive hypertension. We used the patch-clamp technique to examine whether Cyp-epoxygenase-dependent AA metabolites inhibited the basolateral 40-pS K+channel (Kir4.1/
Ming-Xiao, Wang +5 more
openaire +3 more sources
Impaired CO2 sensitivity of astrocytes in a mouse model of Rett syndrome [PDF]
, 2015 Rett syndrome is a prototypical neurological disorder characterised by abnormal breathing pattern and reduced ventilatory CO2 sensitivity. Medullary astrocytes are a crucial component of central CO2 /pH chemosensitivity.
Abdala, AP +3 more
core +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels
British Journal of Pharmacology, Volume 178, Issue S1, Page S157-S245, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +57 more
wiley +1 more source
Essential role of Kir5.1 channels in renal salt handling and blood pressure control [PDF]
JCI Insight, 2017 Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly rectifying K+ channels Kir4.1 (Kcnj10) and Kir5.1 (Kcnj16) are highly expressed in the basolateral membrane of distal renal tubules and contribute to Na+ reabsorption and K+ secretion through the direct control of transepithelial voltage.
Oleg Palygin +8 more
openaire +2 more sources
Genetic variants in eleven central and peripheral chemoreceptor genes in sudden infant death syndrome [PDF]
, 2022 Background: Sudden infant death syndrome (SIDS) is still one of the leading causes of postnatal infant death in developed countries. The occurrence of SIDS is described by a multifactorial etiology that involves the respiratory control system including ...
Both, Christian Peter +5 more
core +1 more source
Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron.
Am J Physiol Cell Physiol, 2022 The inwardly rectifying potassium channel (Kir) 4.1 (encoded by KCNJ10) interacts with Kir5.1 (encoded by KCNJ16) to form a major basolateral K+ channel in the renal distal convoluted tubule (DCT), connecting tubule (CNT), and the cortical collecting duct (CCD). Kir4.1/Kir5.1 heterotetramer plays an important role in regulating Na+ and K+ transport in
Wang WH, Lin DH.
europepmc +3 more sources
Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy [PDF]
, 2016 Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity.
Ambrosini, Elena +17 more
core +1 more source