Results 51 to 60 of about 1,066 (149)

Deletion of Kir5.1 Impairs Renal Ability to Excrete Potassium during Increased Dietary Potassium Intake [PDF]

Journal of the American Society of Nephrology, 2019
Significance Statement In the distal convoluted tubule, the basolateral inwardly rectifying potassium channel, a heterotetramer of Kir4.1 and Kir5.1, plays an important role in the regulation of potassium excretion by determining the activity of the thiazide-sensitive sodium-chloride cotransporter (NCC). Previous research found
Peng Wu, Zhong-Xiuzi Gao, Dan-Dan Zhang, Xiao-Tong Su, Wen-Hui Wang, Dao-Hong Lin   +5 more
openaire   +2 more sources

Kir4.1/Kir5.1 channels possess strong intrinsic inward rectification determined by a voltage-dependent K+-flux gating mechanism. [PDF]

J Gen Physiol, 2021
Inwardly rectifying potassium (Kir) channels are broadly expressed in both excitable and nonexcitable tissues, where they contribute to a wide variety of cellular functions. Numerous studies have established that rectification of Kir channels is not an inherent property of the channel protein itself, but rather reflects strong voltage dependence of ...
Marmolejo-Murillo LG, Aréchiga-Figueroa IA, Moreno-Galindo EG, Ferrer T, Zamora-Cárdenas R, Navarro-Polanco RA, Sánchez-Chapula JA, Rodríguez-Menchaca AA.   +7 more
europepmc   +4 more sources

Genetic deletion of TREK-1 or TWIK-1/TREK-1 potassium channels does not alter the basic electrophysiological properties of mature hippocampal astrocytes in situ

Frontiers in Cellular Neuroscience, 2016
We have recently shown that a linear current-to-voltage (I-V) relationship of membrane conductance (passive conductance) reflects the intrinsic property of K+ channels in mature astrocytes. While passive conductance is known to underpin a highly negative
Yixing eDu, Yixing eDu, Conrad M. Kiyoshi, Qi eWang, Qi eWang, Wei eWang, Bao Feng eMa, Catherine C. Alford, Shiying eZhong, Qi eWan, Haijun eChen, Eric Edward Lloyd, Robert M Bryan, Min eZhou   +13 more
doaj   +1 more source

The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion [PDF]

, 2016
Citation: Miyazaki, H., Wangemann, P., & Marcus, D. C. (2016). The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiology, 17(1), 1.
Marcus, Daniel C., Miyazaki, Hiromitsu, Wangemann, Antje Philine   +2 more
core   +1 more source

PSD-95 Mediates Formation of a Functional Homomeric Kir5.1 Channel in the Brain [PDF]

Neuron, 2002
Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on the plasma membrane in a clustered
Tanemoto, Masayuki, Fujita, Akikazu, Higashi, Kayoko, Kurachi, Yoshihisa   +3 more
openaire   +2 more sources

Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine-induced temporal lobe epilepsy model

Frontiers in Cellular Neuroscience, 2013
The inwardly-rectifying potassium (Kir) channel Kir4.1 in brain astrocytes mediates spatial K+ buffering and regulates neural activities. Recent studies have shown that loss-of-function mutations in the human gene KCNJ10 encoding Kir4.1 cause epileptic ...
Yuki eNagao, Yuya eHarada, Takahiro eMukai, Saki eShimizu, Aoi eOkuda, Megumi eFujimoto, Asuka eOno, Yoshihisa eSakagami, Yukihiro eOhno   +8 more
doaj   +1 more source

The emerging role of the inwardly rectifying K+ channels in autism spectrum disorders and epilepsy [PDF]

, 2011
Autism is a complex behavioral disorder that develops prior to age three years and is distinguished by high heritability. Many genes predisposing to autism spectrum disorders (ASDs) have been identified.
D’Adamo, Maria Cristina, Imbrici, Paola, Martino, Dianda, Moro, Francesca, Pessia, Mauro, Roscini, Mauro, Santorelli, Filippo Maria, Sicca, Federico   +7 more
core  

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Caractérisation des canaux potassiques du tubule contourné proximal et des propriétés régulatrices des canaux chlorure de la membrane basolatérale des cellules intercalaires du tubule connecteur [PDF]

, 2015
A 10 pS chloride channel at the basolateral side of connecting duct intercalated cells shares properties with the cloned ClC-K2 channel. Patch-clamp experiments show that its activity and the number of active channels increase with (i) membrane ...
Pinelli, Laurent
core   +2 more sources

Unique features of seizure‐induced cardiorespiratory failure in SSKcnj16−/− rats: Implications for sudden unexpected death in epilepsy

Epilepsia, Volume 66, Issue 7, Page 2578-2591, July 2025.
Abstract Objective Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure‐induced disruption of vital physiological systems. The objective of this study was to characterize seizure‐induced physiological dysfunction leading to death in SSKcnj16−/− rats and ...
Melissa Eilbes, Alexander Gallo, Wasif A. Osmani, Paloma Bittencourt‐Silva, Anna D. Manis, Matthew R. Hodges   +5 more
wiley   +1 more source