Results 61 to 70 of about 1,066 (149)

Inwardly rectifying potassium channels (KIR) in GtoPdb v.2021.3 [PDF]

, 2021
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x)
Adelman, John P., Clapham, David E., Hibino, Hiroshi, Inanobe, Atsushi, Jan, Lily Y., Karschin, Andreas, Kubo, Yoshihiro, Kurachi, Yoshihisa, Lazdunski, Michel, Miki, Takashi, Nichols, Colin G., Palmer, Lawrence G., Pearson, Wade L., Sackin, Henry, Seino, Susumu, Slesinger, Paul A., Tucker, Stephen, Vandenberg, Carol A.   +17 more
core   +3 more sources

pH Dependence of the Inwardly Rectifying Potassium Channel, Kir5.1, and Localization in Renal Tubular Epithelia [PDF]

Journal of Biological Chemistry, 2000
The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed.
TUCKER J. S., IMBRICI P., SALVATORE L., D'ADAMO, Maria Cristina, PESSIA, Mauro   +4 more
openaire   +5 more sources

Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function

The Journal of Physiology, Volume 603, Issue 12, Page 3499-3518, 15 June 2025.
Abstract figure legend Pathogenic impact of the PD‐linked Kir4.2R28C mutation on Kir4.2 channel proteostasis and function. The Kir4.2R28C mutation, identified in a familial Parkinson's disease (PD) pedigree, leads to a near‐complete loss of potassium channel function and exerts a significant dominant‐negative effect.
Xiaoyi Chen, Rocio K. Finol‐Urdaneta, Mo Chen, Alex M. Sykes, Bingmiao Gao, Jamila Iqbal, David J. Adams, George D. Mellick, Linlin Ma   +8 more
wiley   +1 more source

Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits. [PDF]

, 2016
Two-pore domain (K2P) potassium channels are the major molecular correlates of the background (leak) K+ current in a wide variety of cell types. They generally play a key role in setting the resting membrane potential and regulate the response of ...
Czirják Gábor, Enyedi Péter, Lengyel Miklós   +2 more
core   +1 more source

Potassium homeostasis during disease progression of Alzheimer's disease

The Journal of Physiology, Volume 603, Issue 11, Page 3405-3424, 1 June 2025.
Abstract figure legend Schematic diagram depicting astrocytic potassium (K+) clearance in the hippocampus of healthy brain (left) and during progression of Alzheimer's disease. Reduced conductivity through Kir channels and gap junctions in hippocampal astrocytes impair their ability to clear K+ from the extracellular milleu, which results in a ...
Evgeniia Samokhina, Armaan Mangat, Chandra S. Malladi, Erika Gyengesi, John W. Morley, Yossi Buskila   +5 more
wiley   +1 more source

Potassium channels in epithelial transport [PDF]

, 2018
Epithelial cells in the kidney, gastrointestinal tract and exocrine glands are engaged in vectorial transport of salt and nutrients. In these tissues, K+ channels play an important role for the stabilization of membrane voltage and maintenance of the ...
Warth, Richard
core  

Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels

American Journal of Physiology-Cell Physiology, 2003
Heteromultimerization between different inwardly rectifying (Kir) potassium channel subunits is an important mechanism for the generation of functional diversity. However, little is known about the mechanisms that control this process and that prevent promiscuous interactions in cells that express many different Kir subunits.
Konstas, A, Korbmacher, C, Tucker, S
openaire   +3 more sources

The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. [PDF]

, 2016
The heart is controlled by the sympathetic and parasympathetic limbs of the autonomic nervous system with inhibitory signaling mechanisms recruited in both limbs.
Aziz, Bowman, Boychuk, Carmichael, Desai, Dolphin, Finlay, Guyenet, Head, Horiuchi, Izzo, LaVallie, Lopez, Luscher, Ma, Machhada, Madden, Madden, Marina, Marina, Nalivaiko, Nalivaiko, Ng, Ngampramuan, Nolan, Onodera, Parker, Paton, Paton, Richter, Rong, Schreihofer, Sebastian, Spyer, Sternweis, Strack, Trapp, Ustyugova, Vaseghi, Verrier, Wainford, Zuberi, Zuberi   +42 more
core   +2 more sources

Modulation of Kir4.2 rectification properties and pHi-sensitive run-down by association with Kir5.1

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Inwardly rectifying K+ channels (Kir) comprise seven subfamilies that can be subdivided further on the basis of cytosolic pH (pHi) sensitivity, rectification strength and kinetics, and resistance to run-down. Although distinct residues within each channel subunit define these properties, heteromeric association with other Kir subunits can modulate them.
Lam, Hung D., Lemay, Anne-Marie, Briggs, M. Martha, Yung, Marco, Hill, Ceredwyn E.   +4 more
openaire   +2 more sources

Regulation of ClC‐K/barttin by endocytosis influences distal convoluted tubule hyperplasia

The Journal of Physiology, Volume 602, Issue 17, Page 4291-4307, 1 September 2024.
Abstract figure legend ClC‐K/barttin channels mediate chloride transport in the kidney and inner ear. Mutating tyrosine 98 to alanine in barttin increases function by an unknown mechanism. In the present study, we performed experiments in oocytes and kidney cells, showing that tyrosine 98 is part of an endocytic motif.
Clara Mayayo‐Vallverdú, Héctor Gaitán‐Peñas, Mercedes Armand‐Ugon, Ashraf Muhaisen, Esther Prat, Aida Castellanos, Xabier Elorza‐Vidal, Miguel López de Heredia, Marta Alonso‐Gardón, Carla Pérez‐Rius, Marta Vecino‐Pérez, Adrián Mallen, Ekaitz Errasti‐Murugarren, Miguel Hueso, Rafael Artuch, Virginia Nunes, Raúl Estévez   +16 more
wiley   +1 more source