Results 71 to 80 of about 1,066 (149)

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity [PDF]

Journal of Biological Chemistry, 2011
The molecular identity of ion channels which confer PCO(2)/pH sensitivity in the brain is unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory control, including the locus coeruleus.
D'Adamo MC, Shang L, Brown SDM, Pessia M, Tucker SJ, IMBRICI, Paola   +5 more
openaire   +4 more sources

Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia

BioFactors, Volume 50, Issue 3, Page 523-541, May/June 2024.
The inward rectifying K+ channel Kir2.1 plays a major role in extracellular potassium buffering in the brain. Here we show that in cellular models of aging neuroglia characterized by an elevated oxidative stress, the Kir2.1‐induced current is dramatically reduced. This loss of function resulted from a reduction in protein abundance, with no alterations
Alessia Remigante, Sara Spinelli, Paolo Zuccolini, Paola Gavazzo, Angela Marino, Michael Pusch, Rossana Morabito, Silvia Dossena   +7 more
wiley   +1 more source

Knockout of Kcnj16 (Kir5.1) in Dahl Salt‐Sensitive Rats Produces Seizure Phenotype

The FASEB Journal, 2018
Kir5.1 is a member of an inwardly rectifying potassium (Kir) channel family notably present in the kidney and brain. We previously established that a knockout rat model of Kcnj16 (gene encoding Kir5.1) on a Dahl salt‐sensitive background (SS Kcnj16−/− )
Anna D. Manis, Matthew R. Hodges, Tengis S. Pavlov, Alexander Staruschenko, Oleg Palygin   +4 more
openaire   +1 more source

Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x)
Adelman, John P., Clapham, David E., Hibino, Hiroshi, Inanobe, Atsushi, Jan, Lily Y., Karschin, Andreas, Kubo, Yoshihiro, Kurachi, Yoshihisa, Lazdunski, Michel, Miki, Takashi, Nichols, Colin G., Palmer, Lawrence G., Pearson, Wade L., Sackin, Henry, Seino, Susumu, Slesinger, Paul A., Tucker, Stephen, Vandenberg, Carol A.   +17 more
core   +2 more sources

Astrocyte‐like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells

Glia, Volume 72, Issue 2, Page 245-273, February 2024.
Main Points Subpopulations of NG2 glia in the healthy and ischemic adult cortex were identified based on their gene expression and membrane properties. Astrocyte‐like NG2 glia exhibit neurogenic gene expression and are more abundant in post‐ischemic tissue.
Lucie Janeckova, Tomas Knotek, Jan Kriska, Zuzana Hermanova, Denisa Kirdajova, Jan Kubovciak, Linda Berkova, Jana Tureckova, Sara Camacho Garcia, Katerina Galuskova, Michal Kolar, Miroslava Anderova, Vladimir Korinek   +12 more
wiley   +1 more source

Kir4.1/Kir5.1 Activity Is Essential for Dietary Sodium Intake–Induced Modulation of Na-Cl Cotransporter [PDF]

Journal of the American Society of Nephrology, 2018
Significance Statement Considerable evidence indicates that basolateral inwardly rectifying potassium channel Kir4.1/Kir5.1 is essential for membrane transport in the distal convoluted tubule (DCT), and that dietary sodium and potassium are important in regulating activity of the thiazide-sensitive Na-Cl cotransporter (NCC). In
Peng, Wu, Zhong-Xiuzi, Gao, Xiao-Tong, Su, Ming-Xiao, Wang, Wen-Hui, Wang, Dao-Hong, Lin   +5 more
openaire   +2 more sources

Idiopathic epilepsy of childhood and potassium ion channels [PDF]

, 2007
Potassium can affect the development of common seizure type and can be defined seizure susceptibility allele. The existence of inward-rectifying potassium (Kir) channels was first recognized half a century ago. The biophysical fingerprint of Kir channels
Dai, Alper I, Wasay, Mohammad
core   +1 more source

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).

Experimental physiology, 2011
Inward rectifier (Kir) potassium channels contribute to the control of electrical activity in excitable tissues and their activity is modulated by many biochemical factors, including protons. Heteromeric Kir4.1-Kir5.1 channels are highly pH sensitive within the physiological range of pH changes and are strongly expressed by the peripheral chemosensors ...
Trapp, S, Tucker, S, Gourine, A
openaire   +3 more sources

Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal

Biomolecules
Attraction of glioblastoma cells to potassium was suspected when glioblastoma cells clustered around dying cells and migrated towards serum (high [K+]) and increased potassium.
Marie E. Beckner
doaj   +1 more source

Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype [PDF]

, 2015
none21Short QT3 syndrome (SQT3S) is a cardiac disorder characterized by a high risk of mortality and associated with mutations in Kir2.1 (KCNJ2) channels.

core   +1 more source