Results 11 to 20 of about 3,910 (125)

A Comprehensive Multiomics Signature of Doxorubicin-Induced Cellular Senescence in the Postmenopausal Human Ovary. [PDF]

Aging Cell
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Devrukhkar PR, Watson MA, Soygur B, Wu F, Bons J, Anvari H, Atazhanova T, Martin N, Tran T, Schneider K, Rose JP, Winer D, Shanes E, Pavone MEG, Campisi J, Furman D, Melov S, Schilling B, Duncan FE.   +18 more
europepmc   +2 more sources

The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses. [PDF]

Biomed Res Int, 2013
T lymphocytes from the immune system are bone marrow‐derived cells whose development and activities are carefully supervised by two sets of accessory cells. In the thymus, the immature young T lymphocytes are engulfed by epithelial “nurse cells” and retained in vacuoles, where most of them (95%) are negatively selected and removed when they have an ...
Reyes García MG, García Tamayo F.
europepmc   +2 more sources

Interaction with adenylate cyclase toxin from Bordetella pertussis affects the metal binding properties of calmodulin. [PDF]

FEBS Open Bio, 2017
The metal binding properties of calmodulin (CaM) were examined in the presence of the catalytic domain of Bordetella pertussis adenylate cyclase toxin domain (CyaA‐ACD). Interaction with CyaA‐ACD modified calcium and magnesium binding properties in CaM.
Springer TI, Emerson CC, Johns CW, Finley NL.   +3 more
europepmc   +2 more sources

EAACI Molecular Allergology User's Guide 2.0

Pediatric Allergy and Immunology, Volume 34, Issue S28, March 2023., 2023
Abstract Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of ...
Stephanie Dramburg, Christiane Hilger, Alexandra F. Santos, Leticia de las Vecillas, Rob C. Aalberse, Nathalie Acevedo, Lorenz Aglas, Friedrich Altmann, Karla L. Arruda, Riccardo Asero, Barbara Ballmer‐Weber, Domingo Barber, Kirsten Beyer, Tilo Biedermann, Maria Beatrice Bilo, Simon Blank, Philipp P. Bosshard, Heimo Breiteneder, Helen A. Brough, Merima Bublin, Dianne Campbell, Luis Caraballo, Jean Christoph Caubet, Giorgio Celi, Martin D. Chapman, Maksymilian Chruszcz, Adnan Custovic, Rebecca Czolk, Janet Davies, Nikolaos Douladiris, Bernadette Eberlein, Motohiro Ebisawa, Anna Ehlers, Philippe Eigenmann, Gabriele Gadermaier, Mattia Giovannini, Francisca Gomez, Rebecca Grohman, Carole Guillet, Christine Hafner, Robert G. Hamilton, Michael Hauser, Thomas Hawranek, Hans Jürgen Hoffmann, Thomas Holzhauser, Tomona Iizuka, Alain Jacquet, Thilo Jakob, Bente Janssen‐Weets, Uta Jappe, Marek Jutel, Tanja Kalic, Sandip Kamath, Sabine Kespohl, Jörg Kleine‐Tebbe, Edward Knol, André Knulst, Jon R. Konradsen, Peter Korošec, Annette Kuehn, Gideon Lack, Thuy‐My Le, Andreas Lopata, Olga Luengo, Mika Mäkelä, Alessandro Maria Marra, Clare Mills, Martine Morisset, Antonella Muraro, Anna Nowak‐Wegrzyn, Roni Nugraha, Markus Ollert, Kati Palosuo, Elide Anna Pastorello, Sarita Ulhas Patil, Thomas Platts‐Mills, Anna Pomés, Pascal Poncet, Ekaterina Potapova, Lars K. Poulsen, Christian Radauer, Suzana Radulovic, Monika Raulf, Pierre Rougé, Joaquin Sastre, Sakura Sato, Enrico Scala, Johannes M. Schmid, Peter Schmid‐Grendelmeier, Denise Schrama, Hélène Sénéchal, Claudia Traidl‐Hoffmann, Marcela Valverde‐Monge, Marianne van Hage, Ronald van Ree, Kitty Verhoeckx, Stefan Vieths, Magnus Wickman, Josefina Zakzuk, Paolo M. Matricardi, Karin Hoffmann‐Sommergruber   +100 more
wiley   +1 more source

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9‐month equine groove model study

Journal of Orthopaedic Research, Volume 39, Issue 11, Page 2363-2375, November 2021., 2021
Abstract This study aimed to quantify the long‐term progression of blunt and sharp cartilage defects and their effect on joint homeostasis and function of the equine carpus. In nine adult Shetland ponies, the cartilage in the radiocarpal and middle carpal joint of one front limb was grooved (blunt or sharp randomized). The ponies were subjected to an 8‐
Nikae C. R. te Moller, Ali Mohammadi, Saskia Plomp, Filipe M. Serra Bragança, Martijn Beukers, Behdad Pouran, Isaac O. Afara, Ervin Nippolainen, Janne T. A. Mäkelä, Rami K. Korhonen, Juha Töyräs, Harold Brommer, P. René van Weeren   +12 more
wiley   +1 more source

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]

, 2015
Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA, FAZIO, FRANCESCO, Lionetto, L, MARTELLETTI, Paolo, Mitsikostas, Dd   +4 more
core   +1 more source

Determining the 7Li(n,gamma) cross section via Coulomb dissociation of 8Li [PDF]

, 2013
The applicability of Coulomb dissociation reactions to determine the cross section for the inverse neutron capture reaction was explored using the reaction 8Li(gamma,n)7Li. A 69.5 MeV/nucleon 8Li beam was incident on a Pb target, and the outgoing neutron
Baumann, T., Bazin, D., Bertulani, C. A., Bordeanu, C., Carlin, N., Csanad, M., Deak, F., DeYoung, P., Frank, N., Fukuchi, T., Fulop, Zs., Gade, A., Galaviz, D., Galonsky, A., Hoffman, C. R., Horvath, A., Ieki, K., Izsak, R., Kiss, A., Peters, W. A., Schelin, H., Seres, Z., Thoennessen, M., Veres, G. I.   +23 more
core   +3 more sources

Optical Properties, Chemical Composition and the Toxicological Potential of Urban Particulate Matter [PDF]

, 2017
This paper discusses the diurnal variation and the interdependences between the physical, chemical and toxicological characteristics of atmospheric carbonaceous particulate matter (CPM) and co-emitted gaseous components.
Ajtai, Tibor, Bozóki, Zoltán, Gelencsér, András, Horváth, Eszter, Imre, Kornélia, Jancsek- Turóczi, Beatrix, Kiss-Albert, Gergely, Kováts, Nóra, Manczinger, László, Palágyi, Andrea, Pintér, Máté, Szabó, Gábor, Utry, Noémi, Vágvölgyi, Csaba   +13 more
core   +1 more source

Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine [PDF]

, 2015
Energy-efficient buildings can make a major contribution to tackle the world’s climate change and energy use. A number of different environmental certification systems have been created to support energy-efficient and environmentally friendly buildings ...
Tajti, János, Tuka, Bernadett, Botz, Bálint, Helyes, Zsuzsanna, Vécsei, László   +4 more
core   +1 more source

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]

, 2018
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon, Baca, Serapio M, Waschek, James A   +2 more
core   +2 more sources