Results 181 to 190 of about 571,004 (286)

Host-Specific Circulation and Molecular Diversity of <i>Babesia</i>, <i>Hepatozoon</i> and <i>Bartonella</i> Species Among Wild Carnivores in Northwestern Italy. [PDF]

Animals (Basel)
Sel E, Moroni B, Robetto S, Garcia-Vozmediano A, De Paolis L, Carella E, Libertini G, Verin R, Orusa R, Zoppi S, Razzuoli E, Listorti V, Guardone L.   +12 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Detection and Phylogenetic Characterization of Canine Distemper Virus (<i>Morbillivirus canis</i>) in Wild Foxes and Badgers from Northern Italy in 2021-2026. [PDF]

Animals (Basel)
Filippi A, Lauzi S, Garbarino C, Reggiani A, Rossi R, Ferrari F, Massella E, Luppi A, Santi A, Moreno A, Marelli A, Carra E.   +11 more
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Genome of an <i>Escherichia coli</i> engineered for improved control over polyhydroxyalkanoate monomer composition. [PDF]

Microbiol Resour Announc
Mejia RE, Tran PQ, Kumar D, Fox BG, Majumder EL-W.   +4 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Correction to "The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis". [PDF]

Aging Cell
europepmc   +1 more source

Whole genome sequences of novel <i>Staphylococcus epidermidis</i>, <i>Streptococcus salivarius</i>, and <i>Streptococcus anginosus</i> strains isolated from human gastric biopsy tissue. [PDF]

Microbiol Resour Announc
Mannion A, Shen Z, Dzink-Fox J, Piazuelo MB, Wilson KT, Peek RM, Fox JG.   +6 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Arctic Fox-Derived <i>Lactiplantibacillus plantarum</i> J3 Alleviates Colitis in Mice in Association with Strengthening of the Intestinal Barrier and Reshaping of the Intestinal Flora. [PDF]

Life (Basel)
Sun Y, Lv J, Meng X, Sun Y, Fu H, Xu W, Du Z.   +6 more
europepmc   +1 more source