Results 211 to 220 of about 54,134 (244)

PPAR-γ agonist stabilizes KLF4 protein via activating Akt signaling and reducing KLF4 ubiquitination

Biochemical and Biophysical Research Communications, 2014
Peroxisome proliferator activated receptor γ (PPAR-γ) plays important roles in cell cycle regulation, differentiation and apoptosis. Krüppel-like factor 4 (KLF4) modulates vascular smooth muscle cell (VSMC) phenotype. Both KLF4 and PPAR-γ are involved in VSMC proliferation and differentiation. However, the actual relationship between KLF4 and PPAR-γ in
Jin-Kun Wen
exaly   +3 more sources

Role of lipid metabolism gene KLF4 in osteoarthritis

Clinical Rheumatology, 2023
Osteoarthritis (OA) is a common degenerative disease of joints, which can appear in almost any joint of the body. Therefore, the widespread occurrence of this disease has a huge impact on the lives of patients around the world. As an important part of metabolism, lipid metabolism is closely related to the occurrence and development of osteoarthritis.We
Kaibo Hu, Yuan Shu, Zuxi Feng, Mi Zou, Jiazhe Luo, Ziyue Wei, Jie Peng, Liang Hao   +7 more
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Zebrafish KLF4 Is Essential for Primitive Haematopoiesis.

Blood, 2005
Abstract Gene knockout studies of Krüppel-like factors (KLFs) in mice have demonstrated key roles in organogenesis. EKLF (Klf1) plays an essential role in definitive erythropoiesis and b-globin gene expression, but primitive (yolk sac) erythropoiesis and embryonic globin gene expression are essentially normal.
Perkins, Andrew C., Gardiner, Melissa R.
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The Role of KLF4 in Alzheimer’s Disease [PDF]

Frontiers in Cellular Neuroscience, 2018
Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF4's critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer's disease (AD), indicating that KLF4 might be a potential ...
Ziqian Cheng, Yang Jin, shuohui Gao
exaly   +4 more sources

Altered expression of the KLF4 in colorectal cancers

Pathology - Research and Practice, 2006
KLF4 is an important regulator of cell proliferation and is maximally expressed in epithelial cells of the gastrointestinal tract. Inactivation of the KLF4 gene by genetic and epigenetic alterations has been reported in colorectal cancers, but the expression pattern of the KLF4 protein has not been studied.
Byung Joon, Choi, Yong Gu, Cho, Jae Whie, Song, Chang Jae, Kim, Su Young, Kim, Suk Woo, Nam, Nam Jin, Yoo, Jung Young, Lee, Won Sang, Park   +8 more
openaire   +2 more sources

KLF4: A novel target for the treatment of atherosclerosis

Medical Hypotheses, 2008
Atherosclerosis is an inflammatory disease characterized by a large amount of hyperproliferation and poorly differentiated or undifferentiated smooth muscle cells in atherosclerotic plaque. Cancer cells differ from normal cells in many aspects, including hyperproliferation and loss of differentiation.
Fang-fang, Yan, Yun-Fang, Liu, Yan, Liu, Yu-Xia, Zhao   +3 more
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The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes

Acta Histochemica, 2022
KLF4 expression has been associated with hair color in mammals and has also been found to regulate melanoma cell growth. Here, we assessed the influence of KLF4 on coat color formation and melanocytes. We found that KLF4 was highly expressed in the black skin of sheep both at the mRNA and protein levels compared with white skin.
Hong, Qin, Yuxiao, Chen, Shuai, Wang, Shihao, Ge, Quanhai, Pang   +4 more
openaire   +2 more sources

KLF4 positively regulates human ghrelin expression

Biochemical Journal, 2009
Ghrelin, an endogenous ligand of the GH (growth hormone) secretagogue receptor, influences many metabolic processes including GH secretion, food intake, energy balance, insulin secretion and adipogenesis. Although ghrelin exhibits a variety of biological functions, the mechanism by which ghrelin expression is regulated is unknown.
Hyo Jung, Lee, Young Mi, Kang, Chang Suk, Moon, Myung Kuk, Joe, Joo Hyun, Lim, Young Ho, Suh, Jihyun, Song, Myeong Ho, Jung   +7 more
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KLF4 signalling in carcinogenesis and epigenetic regulation of hTERT

Medical Hypotheses, 2018
Gene expression is crucial and tightly regulated to steer the development, differentiation, proliferation and even apoptosis of a cell. Each cell and tissue type shows a unique repertoire of transcription factors. Tissue micro-environmental regulation of epigenetic signature of a gene has been documented in many cases.
Suresh Singh, Yadav, Rohini Ravindran, Nair, Pramod Kumar, Yadava   +2 more
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Prognostic significance of NANOG and KLF4 for breast cancer

Breast Cancer, 2012
Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4,
Takuya, Nagata, Yutaka, Shimada, Shinichi, Sekine, Ryota, Hori, Koshi, Matsui, Tomoyuki, Okumura, Shigeaki, Sawada, Junya, Fukuoka, Kazuhiro, Tsukada   +8 more
openaire   +2 more sources