Results 301 to 310 of about 61,743 (326)

pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells

Science immunology, 2023
Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during immune responses, ranging from initial viral control through the production of type I interferons to antigen presentation.
P. F. Rodrigues, Athanasios Kouklas, Grozdan Cvijetic, N. Bouladoux, Mladen Mitrovic, Jigar V. Desai, Djalma S. Lima-Junior, M. Lionakis, Y. Belkaid, R. Ivanek, R. Tussiwand   +10 more
semanticscholar   +1 more source

Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK

Science Signaling, 2023
Macrophages clear apoptotic cells through a process called continual efferocytosis. We found that protocatechuic acid (PCA), a polyphenolic compound abundant in fruits and vegetables, increased the continual efferocytic capacity of macrophages and ...
Qing Li, Xiuping Liu, Yushi Du, Xu Zhang, Panyin Xiang, Guanyu Chen, W. Ling, Dongliang Wang   +7 more
semanticscholar   +1 more source

Role of lipid metabolism gene KLF4 in osteoarthritis

Clinical Rheumatology, 2023
Osteoarthritis (OA) is a common degenerative disease of joints, which can appear in almost any joint of the body. Therefore, the widespread occurrence of this disease has a huge impact on the lives of patients around the world. As an important part of metabolism, lipid metabolism is closely related to the occurrence and development of osteoarthritis.We
Kaibo Hu, Yuan Shu, Zuxi Feng, Mi Zou, Jiazhe Luo, Ziyue Wei, Jie Peng, Liang Hao   +7 more
openaire   +2 more sources

SENP1‐KLF4 signalling regulates LPS‐induced macrophage M1 polarization

The FEBS Journal, 2022
Macrophages are very important immune cells and play critical roles in tumour immunity. Macrophage subtypes can be divided into classical polarization (M1 macrophages) and alternative polarization (M2 macrophages) under different microenvironments ...
Kezhou Wang, Jie Xiong, Yiwen Lu, Lifeng Wang, Tian Tian   +4 more
semanticscholar   +1 more source

PPAR-γ agonist stabilizes KLF4 protein via activating Akt signaling and reducing KLF4 ubiquitination

Biochemical and Biophysical Research Communications, 2014
Peroxisome proliferator activated receptor γ (PPAR-γ) plays important roles in cell cycle regulation, differentiation and apoptosis. Krüppel-like factor 4 (KLF4) modulates vascular smooth muscle cell (VSMC) phenotype. Both KLF4 and PPAR-γ are involved in VSMC proliferation and differentiation. However, the actual relationship between KLF4 and PPAR-γ in
Yan, Sun, Bin, Zheng, Xin-hua, Zhang, Ming, He, Zong-wei, Guo, Jin-kun, Wen   +5 more
openaire   +2 more sources

KLF4 positively regulates human ghrelin expression

Biochemical Journal, 2009
Ghrelin, an endogenous ligand of the GH (growth hormone) secretagogue receptor, influences many metabolic processes including GH secretion, food intake, energy balance, insulin secretion and adipogenesis. Although ghrelin exhibits a variety of biological functions, the mechanism by which ghrelin expression is regulated is unknown.
Hyo Jung, Lee, Young Mi, Kang, Chang Suk, Moon, Myung Kuk, Joe, Joo Hyun, Lim, Young Ho, Suh, Jihyun, Song, Myeong Ho, Jung   +7 more
openaire   +2 more sources

KLF4 Exerts Sedative Effects in Pentobarbital-Treated Mice

Journal of Molecular Neuroscience, 2020
KLF4 is a zinc-finger transcription factor that plays an essential role in many biological processes, including neuroinflammation, neuron regeneration, cell proliferation, and apoptosis. Through effects on these processes, KLF4 has likely roles in Alzheimer's disease, Parkinson's disease, and traumatic brain injury.
Ziqian Cheng, Wei Yang, Bingjin Li, Ranji Cui   +3 more
openaire   +2 more sources

Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice.

Chemical Research in Toxicology
Inflammation, oxidative stress, fibrosis, and ferroptosis play important roles in diabetic nephropathy development. Krüppel-like factor 4 (KLF4) is a transcriptional factor, which regulates multiple cell processes and is involved in diabetic nephropathy.
Shengyu Cai, Huizheng Zhu, Lingling Chen, Congcong Yu, Liyuan Su, Kaihua Chen, Yousheng Li   +6 more
semanticscholar   +1 more source

Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission.

Journal of Molecular and Cellular Cardiology, 2022
RATIONAL Excessive mitochondrial fission is considered key process involved in myocardial ischemia/reperfusion (I/R) injury. However, the upstream mechanism remains largely unclear.
Yueyang Li, Zhenyu Xiong, Yufan Jiang, Hao Zhou, L. Yi, Ying Hu, Xiaofeng Zhai, Jie Liu, F. Tian, Yundai Chen   +9 more
semanticscholar   +1 more source

ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4

Cancer Letters, 2019
Krüppel-like factor 4 (KLF4) is an important transcription factor implicated in a variety of essential cellular processes. Aberrant KLF4 expression is closely related to tumourigenesis and tumour progression. The rapid turnover of the KLF4 protein indicates an important role for the posttranslational modifications (PTMs) of KLF4.
Haojing, Zou, Hongyan, Chen, Zhuan, Zhou, Yong, Wan, Zhihua, Liu   +4 more
openaire   +2 more sources