Results 91 to 100 of about 371,395 (290)

Traumatic dislocation of the knee

, 2021
Traumatic dislocation of the knee is a rare condition. Extensive soft tissue damage and neurovascular injury can be associated with dislocation. Two patients with traumatic dislocation of the knee have been treated in our clinic between 1990-1993.
Erol Yalniz, Kenan Saridogan, Emre Orhun
core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Total knee arthroplasty and medial patellofemoral ligament reconstruction for knee osteoarthritis with habitual patellar dislocation: a case report

Frontiers in Surgery
BackgroundKnee osteoarthritis and habitual patellar dislocation are clinically common osteoarticular diseases. However, existing literature lacks reports on their co-occurrence and treatment approaches.
Hanyu Zhou, Hongguang Zhu, Duanbo Lv, Qiaolin Liu, Yinghao Zheng, Facai Lin, Jian Li, Zhenlong Xing   +7 more
doaj   +1 more source

Pathological Knee Dislocation in the Morbidly Obese [PDF]

, 2005
Knee dislocation is often related to high-energy trauma and may be associated with neurovascular damage. Body weight is not usually recognized as a causative factor. However, morbid obesity may be associated with pathological dislocation.
Seenath, M.M., Macdonald, D., Pollard, S.G., Parry, D.J., Scott, D.J.A.   +4 more
core   +1 more source

Accelerating Musculoskeletal Robotics Through Parametric Design and 3D‐Printed Flexible Structures

Advanced Intelligent Systems, EarlyView.
Parametric design and flexible 3D printing create muscle‐, tendon‐, ligament‐, and cushion‐like robotic elements from a single thermoplastic polyurethane material. Tuning lattice patterns adjusts regional mechanical properties and enables coordinated multijoint motions in a life‐sized musculoskeletal leg under external suspension, with partial body ...
Shunnosuke Yoshimura, Kento Kawaharazuka, Kei Okada   +2 more
wiley   +1 more source

Grain size, size-distribution and dislocation structure from diffraction peak profile analysis [PDF]

, 2002
Diffraction peak profile analysis (or Line Profile Analysis, LPA) has recently been developed to such an extent that it can be applied as a powerful method for the characterization of microstructures of crystalline materials in terms of crystallite ...
Gubicza, Jenő, Ungár, Tamás
core   +1 more source

Congenital dislocation of the knee complicated with bilateral hip dislocation: a case report and literature review

BMC Musculoskeletal Disorders
Background Congenital dislocation of the knee is characterised by excessive knee extension or dislocation and anterior subluxation of the proximal tibia, and this disease can occur independently or coexist with different systemic syndromes. Nevertheless,
Bohai Qi, Qiang Jie, Xiaowei Wang, Qingda Lu, Fei Su, Yating Yang   +5 more
doaj   +1 more source

Musculoskeletal Phenotypes of 19 Patients With X‐Linked HNRNPH2‐Related Neurodevelopmental Disorder: A Prospective Case Series

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Detailed clinical phenotypes have been previously reported for 33 individuals with X‐linked HNRNPH2‐related neurodevelopmental disorder. Of these, 75% self‐reported a musculoskeletal abnormality, including hip dysplasia, scoliosis, kyphosis, lordosis, pes planus, arthritis, and missing spinous processes.
Ambar Garcia, Rachel Salazar, Nicole Holuba, Franklin E. Paulino, Michael G. Vitale, Jennifer M. Bain, Joshua Hyman   +6 more
wiley   +1 more source