Results 91 to 100 of about 241,971 (301)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Current Classification Systems for Knee Ligament Injuries Are Limited to Ligament Involvement and Do Not Consider Injury Mechanism or Sequence of Injury: A Scoping Review

Arthroscopy, Sports Medicine, and Rehabilitation
Purpose: To systematically assess published classification systems for knee ligament injuries and to propose a comprehensive, multiplanar, sequential knee ligament classification system that improves upon those in the published literature.
Jelle P. van der List, M.D., Ph.D., M.B.A., Roy A.G. Hoogeslag, M.D., Ph.D.   +1 more
doaj   +1 more source

Rehearsal Injuries in Soft-Soled Character Shoes: Injury Rate of Female Collegiate Dancers Wearing Soft-Soled Character Shoes with 2.5 or 3.0 Inch Heels in Musical Theatre Rehearsals [PDF]

, 2018
High-heeled shoes (HHS) have been known to present biomechanical imbalances in lower-leg mechanics at the pedestrian level, but have not been thoroughly studied in the context of highly dynamic movement, such as dance.
Vaughan, Evelyn
core   +1 more source

Coupling angle variability in healthy and patellofemoral pain runners [PDF]

, 2014
Background Patellofemoral pain is hypothesized to result in less joint coordination variability. The ability to relate coordination variability to patellofemoral pain pathology could have many clinical uses; however, evidence to support its clinical ...
Bartlett, Borg, Brian Noehren, Cavanagh, Clark, Cohen, Crossley, David R. Mullineaux, Davis, DeLeo, Dierks, Dierks, Dierks, Dillon, Farrar, Ferber, Ferber, Grood, Hamill, Heidercheit, Heiderscheit, Kelso, Li, Maulder, Mullaney, Mullineaux, Nadeau, Newell, Noehren, Peters, Powers, Powers, Robert Shapiro, Rothman, Sainburg, Sparrow, Stergiou, Söderkvist, Timothy L. Uhl, Tommy J. Cunningham, Willson, Wu   +41 more
core   +1 more source

Knee Multiligament Injury [PDF]

Clinics in Sports Medicine, 2019
Bruce A, Levy, Benjamin, Freychet
openaire   +2 more sources

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

EEG and EMG Sensorimotor Measurements to Assess Proprioception Following ACL Reconstruction [PDF]

, 2018
The Anterior Cruciate Ligament (ACL) is the primary source of rotational stability in the knee by preventing the tibia from sliding in front of the femur. When the ACL is torn, it typically must be repaired through reconstructive surgery which results in
Northrup, Teagan Frances
core   +2 more sources

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Knitted Pneumatic Fabrics for Dynamic Pressure Modulation in Personalized Healthcare Wearables

Advanced Science, EarlyView.
A pneumatic pressure‐regulating knitted fabric (PPKF) is developed, in which knitted pneumatic circuit enables the seamless integration of ultralow radial expansion pneumatic fiber into dual‐channel textile structure. By strategically modulating channel spacing, delivering adjustable dynamic pressures and clinically relevant gradient compression ratios.
Xiaoyu Chen, Jintu Fan, Rong Zheng, Qing Chen, Fengxin Sun, Huanhuan Liu   +5 more
wiley   +1 more source

Acute ankle and knee injuries: To x-ray or not? [PDF]

, 2015
The Ottawa ankle and knee rules are validated clinical decision tools that guide clinicians in targeting radiology to those patients who are likely to have an ankle or knee fracture, thus minimizing x-ray exposure of patients and reducing ...
Fulde, G
core   +1 more source