Results 181 to 190 of about 2,637,067 (408)

Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease‐Specific Neurovascular Plasticity Underlying the Structure‐Pain Relationship

open access: yesAdvanced Science, EarlyView.
This study presents MUSIC, a novel immunostaining and clearing method coupled with large‐field light sheet microscopy, enabling 3D high‐resolution cellular and molecular mapping of intact musculoskeletal joints across species and joint types. Using joint degenerative and injury models, disease‐specific neurovascular alterations are uncovered, revealing
Peng Chen   +18 more
wiley   +1 more source

Investigating magnetic susceptibility of human knee joint at 7 Tesla

open access: yesMagnetic Resonance in Medicine, 2017
Hongjiang Wei   +8 more
semanticscholar   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu   +12 more
wiley   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

open access: yesAdvanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang   +22 more
wiley   +1 more source

Venous Malformations as a Rare Cause of Knee Joint Pain in Children and Young Adults: Clinical and Radiological Manifestations [PDF]

open access: gold
Adam Dobek   +5 more
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

open access: yesAdvanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang   +9 more
wiley   +1 more source

Haemangioma of the Knee Joint [PDF]

open access: yesActa Orthopaedica Scandinavica, 1968
A, Halborg, H, Hansen, H O, Sneppen
openaire   +2 more sources

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

open access: yesAdvanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin   +4 more
wiley   +1 more source

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