Results 171 to 180 of about 756,194 (303)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Farnesyl Diphosphate Synthase Promotes Proliferation of Hepatocellular Carcinoma Cells by Interacting With Glucose-6-Phosphate Dehydrogenase. [PDF]

Cancer Med
Liu J, Zhu Y, Lv J, Hu X, Zhong Y.
europepmc   +1 more source

Knock knock, who's there? [PDF]

, 2018
Debusschere, E., Deneudt, K., Hernandez, F., Mortelmans, J., Reubens, J., Wydooghe, B.   +5 more
core  

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

CRISPR-Cas Technology Turns Chlamydomonas reinhardtii into a Flagship for Algal Biotechnology. [PDF]

Mar Drugs
Antonacci A, Masi A, Vedi V, Colella S, Musella F, Fiorentino G, Scognamiglio V.   +6 more
europepmc   +1 more source

Knock Knock

Journal of Religion & Film, 2015
openaire   +1 more source

A new Hilbert transform in Hermitean Clifford analysis [PDF]

, 2008
Brackx, Fred, De Knock, Bram, De Schepper, Hennie, Sommen, Franciscus   +3 more
core  

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Effect of thought field therapy on the anxiety and depression level of elderly patients with chronic diseases

Huli yanjiu, 2020
ZHANG Yin, GU Feng, XU Lei
doaj  

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci. [PDF]

Nat Commun
Taguchi J, Kikuchi M, Jeon H, Shimizu R, Mori H, Ikawa M, Yamada Y, Sato K, Ikeda T, Yamazaki S, Ozawa M.   +10 more
europepmc   +1 more source