Results 241 to 250 of about 756,194 (303)

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Genome-wide identification of genes involved in beetle odoriferous defensive stink gland function recognizes Laccase2 as the phenoloxidase responsible for toxic para-benzoquinone synthesis. [PDF]

PLoS Genet
Atika B, Lehmann S, Buchberger E, Dan'azumi Isah M, Basirkazerouni Z, Rostás M, Bucher G, Wimmer EA.   +7 more
europepmc   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components. [PDF]

Sci Rep
Hassan SA, Stumpe M, Hui KY, Giraud MN, Albrecht U, Ripperger JA.   +5 more
europepmc   +1 more source

Characterization of a Rice GH5_11 Gene Associated with Endosperm and Seed Traits. [PDF]

Plants (Basel)
Gistelinck K, Madder Z, Verbeke I, Van Damme EJM.   +3 more
europepmc   +1 more source

lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation. [PDF]

Mol Med Rep
Yu L, Zhou N, Zhang XL, Pang XJ, Xing L, Pu YJ, Zhang L, Wu JN, Shu H.   +8 more
europepmc   +1 more source

Cell type-specific spatiotemporal control of GFP-tagged protein degradation in mice. [PDF]

J Cell Biol
Prado-Mantilla A, Sheheen J, Underwood J, Lechler T.   +3 more
europepmc   +1 more source