Results 31 to 40 of about 10,320 (211)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

[Fe II] and H2 filaments in the Supernova Remnant G11.2-0.3: Supernova Ejecta and Presupernova Circumstellar Wind

, 2006
We present the results of near-infrared imaging and spectroscopic observations of the young, core-collapse supernova remnant (SNR) G11.2-0.3. In the [Fe II] 1.644 um image, we first discover long, clumpy [Fe II] filaments within the radio shell of the ...
Bon‐Chul Koo, Burton M. G., Dae‐Sik Moon, Green D. A., Green D. A., Ho‐Gyu Lee, Jae‐Joon Lee, Keith Matthews, Keller L. D., Lee H.-G., Nussbaumer H., Oliva E., Oliva E., Rousselot P., Zhang H. L.   +14 more
core   +1 more source

The properties of powerful radio sources at 90 GHz [PDF]

, 2008
‘The definitive version is available at www.blackwell-synergy.com.’ Copyright Blackwell Publishing DOI: 10.1111/j.1365-2966.2008.13370.xPeer ...
Hardcastle, M.J., Looney, L.W.
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The peculiar galaxy IC 1182: An ongoing merger?

, 2003
Broad and narrow band images and long slit spectroscopy of IC1182 are presented. The broad band images reveal a distorted morphology with a large, heavily obscured disk-like structure and several knots in the central region. Galactic material, some of it
Arp, B. Milvang-Jensen, Barnes, Bothun, Calzetti, D. Bettoni, Dickey, Evans, Fasano, G. Fasano, Heckman, Huang, J. Varela, Keel, Khachikian, Koski, M. Moles, Martin, Melnick, Mendes de Oliveira, Mirabel, Márquez, P. Kjærgaard, Rafanelli, Salpeter, Schlegel, Schweizer, Stockton, Veilleux, Viegas-Aldrovandi, Véron, Zezas   +31 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Multifrequency Radiation of Extragalactic Large-Scale Jets

, 2003
Large-scale extragalactic jets, observed to extend from a few to a few hundred kiloparsecs from active galactic nuclei, are now studied over many decades in frequency of electromagnetic spectrum, from radio until (possibly) TeV gamma rays.
Bahcall J. N., Bai J. M., Bai J. M., Begelman M. C., Biretta J. A., Birk G. T., Birkinshaw M., Blandford R., Blundell K. M., Brunetti G., Carilli C. L., Cavallo G., Chartas G., Chartas G., Cheung C. C., Cheung C. C., Chiaberge M., Coleman C. S., Curtis H. D., Danziger I. J., de Vries W. H., Dermer C. D., Fanaroff B. L., Fraix-Burnet D., Fraix-Burnet D., Gabuzda D. C., Giovannini G., Gopal-Krishna, Hardcastle M. J., Harris D. E., Harris D. E., Harris D. E., Harris D. E., Harris D. E., Harris D. E., Heinz S., Hjorth J., Hughes P. A., Komissarov S. S., Komissarov S. S., Kraft R. P., Kraft R. P., Lacombe C., Laing R. A., Laing R. A., Lara L., Mannheim K., Marshall H. L., Marshall H. L., Martel A. R., Meisenheimer K., Meisenheimer K., Neumann M., Nilsson K., Ostrowski M., Perlman E. S., Perlman E. S., Pesce J. E., Rees M. J., Reimer A., Reynolds C. S., Rowell G. P., Röser H.-J., Röser H.-J., Sahayanathan S., Sambruna R. M., Sambruna R. M., Sambruna R. M., Saripalli L., Saripalli L., Scarpa R., Schwartz D. A., Schwartz D. A., Schwartz D. A., Schwartz D. A., Siemiginowska A., Siemiginowska A., Siemiginowska A., Sikora M., Sikora M., Smith D. A., Sparks W. B., Sparks W. B., Stawarz L., Stawarz L., Stawarz L., Swain M. R., Tavecchio F., Wardle J. F. C., Wilson A. S., Wilson A. S., Łukasz Stawarz   +91 more
core   +1 more source

First Evidence of a Precessing Jet Excavating a Protostellar Envelope [PDF]

, 2006
We present new, sensitive, near-infrared images of the Class I protostar, Elias 29, in the Ophiuchus cloud core. To explore the relationship between the infall envelope and the outflow, narrowband H2 1-0 S(1), Br-gamma, and narrowband K-continuum filters
Barsony, Mary, Haisch, Jr., Karl E., Jarrett, Thomas H., Sahai, Raghvendra, Weinberger, Alycia J., Ybarra, Jason E.   +5 more
core   +3 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source