Results 31 to 40 of about 472 (211)

Centrality measures for individual nodes in the SCI meta-proteome.

, 2015
(A) Distribution of protein nodes among the network topological features. Rich-club in red, rich-club knotty centre in gold, network knotty centre in blue and the highest centrality core in green.
Fadi A. Zaraket (779677), Ali Alawieh (779674), Zahraa Sabra (779676), Stephen Tomlinson (326499), Mohammed Sabra (779675)   +4 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

PRUNING Araucaria angustifolia FOR KNOT-FREE TIMBER PRODUCTION

, 2022
Although A. angustifolia is currently economically unimportant, the worldwide trend of conservation through the sustainable use of natural resources together with an intense discussion of governmental regulations and the recent results of genetic ...
Dobner Jr., Mário
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The knotty question of the jet of PKS B1421-490

, 2015
We report the discovery of unusually strong optical and X-ray emission associated with a knot in the radio jet of PKS B1421-490. The knot is the brightest feature observed beyond the radio band, with knot/core flux ratios ∼300 and 3.7 at optical and X-
Gelbord, J M, Godfrey, Leith, Schwartz, D A, Worrall, D M, Jauncey, David L, Murphy, D W, Marshall, H L, Perlman, E S, Birkinshaw, M, Georganopolous, M, Lovell, J E J, Ojha, R   +11 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Growth of pruned eucalypt clone in an agroforestry system in southeastern Brazil

, 2011
This study aimed to identify pruning intensity and frequency that can be applied to eucalypt without imposing growth reduction, in an agroforestry system in Brazil (17°36’ S and 46°42’ W). Pruning treatments included removal of 0, 1/4 and 1/3 of the live
Ramos, Diêgo C., Geraldo G. Reis, Marco A. Monte, Diêgo C. Ramos, Ivan C. I. Fontan, Reis, Maria G. F., Maria G. F. Reis, Helio G. Leite, Fontan, Ivan C. I., Reis, Geraldo G., Monte, Marco A., Felippe C. Souza, Leite, Helio G., Souza, Felippe C.   +13 more
core   +1 more source