Results 151 to 160 of about 13,654,993 (361)

The KATE shell: An implementation of model-based control, monitor and diagnosis [PDF]

open access: yes
The conventional control and monitor software currently used by the Space Center for Space Shuttle processing has many limitations such as high maintenance costs, limited diagnostic capabilities and simulation support.
Cornell, Matthew
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

MULTI-AGENT SYSTEMS : MODELING KNOWLEDGE BASES

open access: yesZbornik radova (Fakultet organizacije i informatike Varaždin), 1999
.. In this paper, we consider modeling knowledge bases in the multi-agent system framework. In the first place, we show how a number of standard assumptions that are made can be expressed in this framework. Afterwards, a fact regarding a priori knowledge about the external world is proved.
Maleković, Mirko, Čubrilo, Mirko
openaire   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

The generic task toolset: High level languages for the construction of planning and problem solving systems [PDF]

open access: yes
The current generation of languages for the construction of knowledge-based systems as being at too low a level of abstraction is criticized, and the need for higher level languages for building problem solving systems is advanced.
Chandrasekaran, B.   +2 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Expanding the knowledge base on actual nutrition as an element of the system of alimentary-dependent diseases prevention [PDF]

open access: diamond, 2020
Larisa Mayurnikova   +4 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

DEVELOPMENT OF CHILDREN COMMUNICATION AT PRIMARY SCHOOL AGE IN COMPUTER-ORIENTED ENVIRONMENT

open access: yesІнформаційні технології і засоби навчання, 2010
The research results of information technologies influence as education environment constituents on development of children communication at primary school age are presented in the article.
Galina P. Lavrentieva
doaj  

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