Results 61 to 70 of about 14,636,841 (366)

Model-Driven Decision Making in Multiple Sclerosis Research: Existing Works and Latest Trends

open access: yesPatterns, 2020
Summary: Multiple sclerosis (MS) is a neurological disorder that strikes the central nervous system. Due to the complexity of this disease, healthcare sectors are increasingly in need of shared clinical decision-making tools to provide practitioners with
Rayan Alshamrani   +4 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Practitioner requirements for integrated Knowledge-Based Engineering in Product Lifecycle Management.

open access: yes, 2008
The effective management of knowledge as capital is considered essential to the success of engineering product/service systems. As Knowledge Management (KM) and Product Lifecycle Management (PLM) practice gain industrial adoption, the question of ...
Bermell-Garcia, Pablo, Fan, Ip-Shing
core   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

A Multi-functional Information Leitstand for Top-Management - A Proposal [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2006
Demand pull and technology push as well as recent initiatives by market-leading software companies indicate that the science of information systems needs to take a new run at the upper layers of management. One of the reasons is the growing importance of
Peter Mertens   +3 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

On the convergence of autonomous agent communities [PDF]

open access: yes, 2010
This is the post-print version of the final published paper that is available from the link below. Copyright @ 2010 IOS Press and the authors.Community is a common phenomenon in natural ecosystems, human societies as well as artificial multi-agent ...
Wang, F, Wang, S, Zhu, H
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

A recommendation method for e-learning environments: the rule-based technique

open access: yesJe-LKS: Journal of E-Learning and Knowledge Society, 2010
The ever growing importance of e-learning over the last decade has triggered an explosion of resources available on the Web. Although this multiplicity of available resources can foster the development of a critical spirit, discernment and the student’s ...
Pierpaolo Di Bitonto   +3 more
doaj   +1 more source

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