Results 61 to 70 of about 9,026,652 (293)
A Multi-functional Information Leitstand for Top-Management - A Proposal [PDF]
Journal of Systemics, Cybernetics and Informatics, 2006 Demand pull and technology push as well as recent initiatives by market-leading software companies indicate that the science of information systems needs to take a new run at the upper layers of management. One of the reasons is the growing importance of
Peter Mertens +3 more
doaj
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Compact integral manifolds of differential systems [PDF]
arXiv, 2010 The boundedness tests for the number of compact integral manifolds of autonomous ordinary differential systems, of autonomous total differential systems, of linear systems of partial differential equations, of Pfaff systems of equations, and of systems of exterior differential equations are proved.
arxiv
Using Structure-Behavior Coalescence Method for Systems Definition 2.0 [PDF]
arXiv, 2021 Systems definition is an artifact created by humans to describe what a system is. A system has been defined, by systems definition 1.0, hopefully to be an integrated whole, embodied in its components, their interrelationships with each other and the environment, and the principles and guidelines governing its design and evolution.
arxiv
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Morphisms of Networks of Hybrid Open Systems [PDF]
arXiv, 2019 This thesis (defended 10/07/2019) develops a theory of networks of hybrid open systems and morphisms. It builds upon a framework of networks of continuous-time open systems as product and interconnection. We work out categorical notions for hybrid systems, deterministic hybrid systems, hybrid open systems, networks of hybrid open systems, and morphisms
arxiv
Contraction analysis of time-varying DAE systems via auxiliary ODE systems [PDF]
arXiv, 2023 This paper studies the contraction property of time-varying differential-algebraic equation (DAE) systems by embedding them to higher-dimension ordinary differential equation (ODE) systems. The first result pertains to the equivalence of the contraction of a DAE system and the uniform global exponential stability (UGES) of its variational DAE system ...
arxiv
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source