Results 61 to 70 of about 13,654,993 (361)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Applied Sciences, 2019 Today, patients generate a massive amount of health records through electronic health records (EHRs). Extracting usable knowledge of patients’ pathological conditions or diagnoses is essential for the reasoning process in rule-based systems to ...
Chao Ou-Yang +4 more
doaj +1 more source
, 2008 The effective management of knowledge as capital is considered essential to the success of engineering product/service systems. As Knowledge Management (KM) and Product Lifecycle Management (PLM) practice gain industrial adoption, the question of ...
Bermell-Garcia, Pablo, Fan, Ip-Shing
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Scientific ReportsThis work explores the potential of connected, digitalized Wire Arc Additive Manufacturing (WAAM) within the framework of Industrie 4.0, analyzing it through distinct process layers: workpiece, assembly, and product. Each layer presents unique timeframes
Samuel Mann +10 more
doaj +1 more source
Towards a powerful knowledge-based system to think outside the box and select multi-purpose plants [PDF]
, 2021 Pierre Silvie, Pierre Martin
openalex +1 more source
The interaction between humans and knowledge management systems : rethinking the future [PDF]
, 2019 In this workshop position paper, we propose a study to understand the importance of knowledge management systems among academics in Saudi higher education institutions, admitting that knowledge workers and Knowledge Management Systems are valuable ...
Almujally, Nouf, Joy, Mike
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
, 1997 Part 1 General techniques and tools: recent advances in knowledge acquisition methodology, S.G. Tzafestas machine learning - a survey, A. Cornuejols and M. Moulet knowledge processing under uncertainty, V. Sridhar modelling inference engine behaviour within knowledge management systems, S.
openaire +2 more sources