Results 71 to 80 of about 13,654,993 (361)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A recommendation method for e-learning environments: the rule-based technique

Je-LKS: Journal of E-Learning and Knowledge Society, 2010
The ever growing importance of e-learning over the last decade has triggered an explosion of resources available on the Web. Although this multiplicity of available resources can foster the development of a critical spirit, discernment and the student’s ...
Pierpaolo Di Bitonto, Maria Laterza, Teresa Roselli, Veronica Rossano   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Systematic Literature Review on Evolvable Knowledge Graphs in Manufacturing

IEEE Access
This systematic literature review investigates how evolvable knowledge graphs (KGs) enhance manufacturing. Evolvable KGs adapt to changing knowledge by leveraging machine learning algorithms and human expertise to improve decision-making, operational ...
Anna Teern, Nada Elgendy, Markus Kelanti, Henna Tammia, Tero Paivarinta   +4 more
doaj   +1 more source

Assessing Ontology Mappings on a Level of Concepts and Instances

IEEE Access, 2020
In recent years, the number of domain ontologies on the Internet has been steadily increasing. Many ontologies describe overlapping universes of discourse in various ways, therefore, the need for an efficient ontology alignment method is required ...
Marcin Pietranik, Adrianna Kozierkiewicz, Mateusz Wesolowski   +2 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Building validation tools for knowledge-based systems [PDF]

The Expert Systems Validation Associate (EVA), a validation system under development at the Lockheed Artificial Intelligence Center for more than a year, provides a wide range of validation tools to check the correctness, consistency and completeness of ...
Chang, C. L., Combs, J. B., Stachowitz, R. A., Stock, T. S.   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Contribution of soil macro-fauna diversity and abundance to soil fertility enhancement in cocoa-based (Theobroma cacao) agroforestry systems in the Littoral Region of Cameroon: An appraisal of cocoa farmers local knowledge [PDF]

, 2021
Roshinus Tsufac Azembouh, Princely Awazi Nyong, Palmer Kfuban Yerima Bernard, Kogge Enang Roger   +3 more
openalex   +1 more source

Knowledge acquisition for case-based reasoning systems [PDF]

Case-based reasoning (CBR) is a simple idea: solve new problems by adapting old solutions to similar problems. The CBR approach offers several potential advantages over rule-based reasoning: rules are not combined blindly in a search for solutions ...
Riesbeck, Christopher K.
core   +1 more source