Results 121 to 130 of about 41,443,645 (306)

The Relationship Learning and Knowledge Based View of Strategy

open access: yesOpen Journal of Business and Management, 2018
The rate of learning is determined by the method that one comes up with the information. The identical substance can be realized often times quicker if properly formulated. This work aims at fostering multidisciplinary dialogue and study about knowledge-intensive methods to learning administration as well as studying procedures in the person ...
openaire   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Dynamic utilisation of knowledge in decision making [PDF]

open access: yes
The contribution of this research is a set of novel insights on the interplay of knowledge assets during decision making. Knowledge is conceptualised as a dynamic resource.
Soskic, Nevena
core  

ACADEMIC SERVICE-LEARNING AS AN INFORMATION SYSTEMS CURRICULUM ASSET [PDF]

open access: yesIssues in Information Systems, 2003
Research in Knowledge Management (KM) has gained distinguished attention in recent years, and different views of methods have been proposed in existing literature. An initial study was the process view that focused on the creation, organization, sharing,
Michael Godfrey
doaj  

The Knowledge-Based View Revisited

open access: yes, 2005
Two of Herbert Simon's best-known papers are "The Architecture of Complexity" and "The Structure of Ill-Structured Problems." We discuss the neglected links between these two papers, highlighting the role of decomposition in the context of problems on which constraints have been imposed as a general approach to problem solving.
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Unpacking the Path from Knowledge Heterogeneity to Team Creativity: A Knowledge-Based View and Dynamic Capability Theory Perspective

open access: yesAdministrative Sciences
This study examines how knowledge heterogeneity affects team creativity in the context of China’s digital intelligence transformation and analyzes the mediating effects of digital intelligence enablement and technology management capability.
Hongyi Cai, Heng Zhao, Yong Huang
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Design issues for knowledge artifacts

open access: yes, 2008
The notion of knowledge artifact has rapidly gained popularity in the fields of general knowledge management and more recently knowledge-based systems. The main goal on this paper is to propose and discuss a methodology for the design and implementation ...
BANDINI, S.   +4 more
core   +1 more source

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