Results 131 to 140 of about 7,833,055 (290)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Genitives, relational nouns, and the argument-modifier distinction [PDF]

, 2013
The argument-modifier distinction is less clear in NPs than in VPs; nouns do not typically take arguments. The clearest cases of arguments in NPs are in certain kinds of nominalizations which retain some "verbal" properties (Grimshaw 1990). The status of
Partee, Barbara H., Borschev, Vladimir
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Argumentation as a Means for Extending Knowledge

Croatian Journal of Philosophy, 2015
In this paper I am developing the theses that argumentation is a means for extending knowledge. The theses are founded on two focal points: 1. Reasoning is designed for argumentation, and 2. Argumentation process is an exceptionally successful media that provokes usage of methods reliable for the extension of knowledge.
openaire   +4 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Shattering a Cartesian Sceptical Dream

Principia: An International Journal of Epistemology, 2004
Scepticism about external world knowledge is frequently claimed to emerge from Descartes’s dreaming argument. That argument supposedly challenges one to have some further knowledge — the knowledge that one is not dreaming that p — if one is to have even ...
Stephen Hetherington
doaj  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Non-interactive arguments of knowledge

Non-interactive arguments of knowledge Cette thèse étudie les arguments de connaissance non-interactives, une brique de base utilisée en cryptographie qui permet à un fournisseur de preuve de convaincre un vérificateur qu'une proposition est vraie sans révéler d'autres informations que la véracité de la proposition.
openaire   +3 more sources

Argumentation, Knowledge and Reasoning

, 2022
This paper deals with Nenad Smokrović’s account of argumentation as a curiosity-driven, cooperative effort. More specifically, I focus on one of the two assumptions on which his account is based: that reasoning is argumentative in nature. Since Smokrović assumes Mercier and Sperber’s argumentative theory as the starting point for developing this ...
openaire   +1 more source