Results 211 to 220 of about 30,775,009 (307)

Research on ontology-based construction risk knowledge base development in deep foundation pit excavation

open access: yesJournal of Asian Architecture and Building Engineering
Facing the massive amount of risk management data for deep foundation pit excavation (DFPE) construction, how to store and utilize these data to prevent the occurrence of risk events is an urgent problem that needs to be solved. The goal of this research
Yuan Chen, Bingge Liang, Hang Hu
doaj   +1 more source

Commonsense Knowledge Editing Based on Free-Text in LLMs [PDF]

open access: yesEMNLP 2024
Knowledge editing technology is crucial for maintaining the accuracy and timeliness of large language models (LLMs) . However, the setting of this task overlooks a significant portion of commonsense knowledge based on free-text in the real world, characterized by broad knowledge scope, long content and non instantiation. The editing objects of previous
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

open access: yesFEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

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