Results 111 to 120 of about 1,199,057 (174)

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

open access: yesAging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

The Long Term Effects of a 12‐Session Community Exercise Program on Health Measures in Cancer Patients

open access: yesAging and Cancer, EarlyView.
ABSTRACT Purpose To assess the long‐term effects of a community cancer exercise program on quality of life, fatigue, weight, waist circumference, physical activity levels, lower extremity strength, body mass index (BMI), heart rate, and blood pressure, across non‐metastatic and metastatic patients.
Isaac Oppong, Roozbeh Naemi
wiley   +1 more source

Crime Against History: Slavery, Race, and the 1776 Report

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT With the 2025 executive order, “Ending Radical Indoctrination in K‐12 Schooling,” the Trump administration reestablished the 1776 Commission, which produced The 1776 Report. This article argues that this report, which is an unsubtle response to The 1619 Project, reveals how White Christian Nationalists wish to mandate that a hyper‐patriotic ...
William V. Trollinger
wiley   +1 more source

From 2D to 3D gamma passing rate tolerance and action limits for patient‐specific quality assurance in volumetric‐modulated arc therapy

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Volumetric modulated arc therapy (VMAT) requires an accurate patient‐specific quality assurance (PSQA) program. In clinical practice, this is usually performed using the γ‐index and the two‐dimensional gamma passing rate (2D %GP). A three‐dimensional (3D) index incorporating the patient anatomy could be more useful for the 3D dose ...
Christos Zarros   +6 more
wiley   +1 more source

Modelling of a double‐scattering proton therapy nozzle using the FLUKA Monte Carlo code and analysis of linear energy transfer in patients treated for prostate cancer

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The dose‐averaged linear energy transfer (LETD) in proton therapy (PT) has in pre‐clinical studies been linked to the relative biological effectiveness (RBE) of protons. Until recently, the most common PT delivery method in prostate cancer has been double‐scattered PT, with LETD only available through dedicated Monte Carlo (MC ...
Rasmus Klitgaard   +7 more
wiley   +1 more source

A review of artificial intelligence in brachytherapy

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen   +4 more
wiley   +1 more source

Impact of enhanced leaf model on dose calculation accuracy in single‐isocenter multitarget stereotactic radiosurgery treatments

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Single‐isocenter multitarget (SIMT) radiosurgery has become increasingly popular as advancement in planning and delivery systems have made this approach clinically viable. With targets varying in size and distance from isocenter, SIMT plans are highly complex with dynamic multileaf collimator (MLC) motion.
Hem Moktan   +3 more
wiley   +1 more source

Evaluating the use of diagnostic CT with flattening filter free beams for palliative radiotherapy: Dosimetric impact of scanner calibration variability

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Palliative radiotherapy comprises a significant portion of the radiation treatment workload. Volumetric‐modulated arc therapy (VMAT) improves dose conformity and, in conjunction with flattening filter free (FFF) delivery, can decrease treatment times, both of which are desirable in a population with a high probability of retreatment ...
Madeleine L. Van de Kleut   +2 more
wiley   +1 more source

Geometric and dosimetric evaluation of a commercial AI auto‐contouring tool on multiple anatomical sites in CT scans

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Current radiotherapy practices rely on manual contouring of CT scans, which is time‐consuming, prone to variability, and requires highly trained experts. There is a need for more efficient and consistent contouring methods. This study evaluated the performance of the Varian Ethos AI auto‐contouring tool to assess its potential integration into
Robert N. Finnegan   +6 more
wiley   +1 more source

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