Results 121 to 130 of about 5,810,256 (329)
Issues on legal knowledge bases traceability
Lietuvos Matematikos Rinkinys, 2007 Requirements traceability is used in many disciplines including system and software engineering. Usually traces are used to describe and follow the life of a requirement, in both a forward and backward directions. Traceability problems are faced in legal
Laima Paliulionienė +1 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Journal of FungiFungi have emerged as versatile biotechnological platforms for addressing environmental challenges with potential co-benefits for human health. Among them, Pleurotus ostreatus stands out for its ligninolytic enzyme systems (notably laccases), capacity to
Luz Miryam Lozada-Martinez +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Радіоелектронні і комп'ютерні системиThe subject of this article is the development of information technologies at the end of the 20th and the beginning of the 21st century for the Fourth Industrial Revolution in the form of Industry 4.0, i.e., Internet of Things (IoT) technologies ...
Serhiy Dotsenko +4 more
doaj +1 more source
NeuType: A Simple and Effective Neural Network Approach for Predicting Missing Entity Type Information in Knowledge Bases [PDF]
, 2019 Jon Arne Bø Hovda +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Changes in regional knowledge bases and its effect on local labour markets in the midst of transition: Evidence from France over 1985-2015. [PDF]
Appl Spat Anal Policy, 2022 Kim K, Kogler DF, Lee C, Kang T.
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source