Results 111 to 120 of about 13,818,015 (276)
Knowledge Adoption: A New Perspective and the Influence of Knowledge Characteristics [PDF]
Proceedings of the Annual Hawaii International Conference on System Sciences, 2019 openaire +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Characteristics of knowledge marketing
Characteristics of knowledge marketing近年、経済における知識の重要性が高まっているものの、既存のマーケティング理論の枠組みでは知識を十分に捉えることができない。いったい知識のマーケティングとはどのようなものなのか議論する必要があり、本稿で知識マーケティングの特性を整理した。調査の結果、「未完成品の取引」「文脈依存性」「顧客志向の必要性」「交渉プロセスの存在」「知識の対称性」の五つが知識マーケティングの特性として導出された。 研究(Article)
openaire +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Relationship Between Knowledge Level and Characteristics of Pulses Seed Growers
Journal of Extension Education, 2016 The study was undertaken to study the relationship between knowledge level and profile characteristics of pulses seed growers. A sample of 90 pulses seed growing farmers was selected from 3 blocks of Coimbatore district in Tamil Nadu.
S. Janani, A. Palaniswamy, M. Balarubini
doaj
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Characteristics and Management of Knowledge Emergence [PDF]
Proceedings of the 3rd Annual 2017 International Conference on Management Science and Engineering (MSE 2017), 2017 Xia Wang, Jie Jin, Li-Jun Zou, Fu Jin
openaire +1 more source