Results 151 to 160 of about 547,727 (260)

Explaining deep neural networks for knowledge discovery in electrocardiogram analysis. [PDF]

Sci Rep, 2021
Hicks SA, Isaksen JL, Thambawita V, Ghouse J, Ahlberg G, Linneberg A, Grarup N, Strümke I, Ellervik C, Olesen MS, Hansen T, Graff C, Holstein-Rathlou NH, Halvorsen P, Maleckar MM, Riegler MA, Kanters JK.   +16 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

MRAgent: an LLM-based automated agent for causal knowledge discovery in disease via Mendelian randomization. [PDF]

Brief Bioinform
Xu W, Luo G, Meng W, Zhai X, Zheng K, Wu J, Li Y, Xing A, Li J, Li Z, Zheng K, Li K.   +11 more
europepmc   +1 more source

Iran diabetes research study; knowledge discovery in diagnosis: a scoping review. [PDF]

J Diabetes Metab Disord, 2021
Fana SE, Ebrahimi R, Esmaeili S, Rambod C, Namazi N, Nasli-Esfahani E, Razi F.   +6 more
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery. [PDF]

J Pharm Anal
Xiao W, Zhang M, Zhao D, Meng F, Tang Q, Hu L, Chen H, Xu Y, Tian Q, Li M, Zhang G, Leng L, Chen S, Song C, Chen W.   +14 more
europepmc   +1 more source

Physician Referral Patterns to Physical Therapists for Managing Knee Osteoarthritis: A Retrospective Analysis of Electronic Health Records From an Integrated Health System

Arthritis Care &Research, EarlyView.
Objective This study aims to describe the frequency and timing of physician referrals to physical therapists (PTs) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja, Joel M. Stevans, Gustavo J. Almeida, Clair Smith, Janet K. Freburger   +4 more
wiley   +1 more source

Knowledge discovery from database: MRI radiomic features to assess recurrence risk in high-grade meningiomas. [PDF]

BMC Med Imaging
Chen C, Hao L, Bai B, Zhang G.
europepmc   +1 more source

Impact of Positive Lifestyle Behaviors on Direct Health Care Cost Savings for Low Back Pain

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate the relationship between a previously purpose‐developed lifestyle behavior scale and health care cost savings related to low back pain (LBP). Methods This longitudinal study used data from the Australian Twin Back (AUTBACK) study. LBP and lifestyle behavior measures were collected at baseline. Physical activity
Ye Tian, Katharine E. Roberts, Michelle Hall, Paula R. Beckenkamp, Angelo Sabag, Karoline Moe, Ana Paula Carvalho‐e‐Silva, Emily J. Callander, Paulo H. Ferreira   +8 more
wiley   +1 more source

Knowledge discovery of patients reviews on breast cancer drugs: Segmentation of side effects using machine learning techniques. [PDF]

Heliyon
Nilashi M, Ahmadi H, Abumalloh RA, Alrizq M, Alghamdi A, Alyami S.   +5 more
europepmc   +1 more source