Results 41 to 50 of about 567,216 (263)

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Marine Natural Products with P-Glycoprotein Inhibitor Properties

Marine Drugs, 2014
P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases.
Dioxelis Lopez, Sergio Martinez-Luis
doaj   +1 more source

Knowledge Discovery in an Agents Environment [PDF]

, 2004
We describe work undertaken to investigate automated querying of simple forms of ontology by software agents to acquire the semantics of metadata terms. Individual terms as well as whole vocabularies can be investigated by agents through a software interface and by humans through an interactive web-based interface.
Manjula Patel, Monica Duke
openaire   +3 more sources

Inpatient Exposure, Confidence, and Knowledge in Pediatric Hematology/Oncology: Evaluating General Pediatric Residents During 2025 ACGME Curriculum Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley   +1 more source

Transferability of a Battery Cell End-of-Life Prediction Model Using Survival Analysis

Energies, 2022
Electric vehicles are increasingly becoming the vehicle of choice in today’s environmentally conscious society, and the heart of an electric vehicle is its battery. Today, lithium-ion batteries are mainly used to power electric vehicles for its increased
Maya Santhira Sekeran, Milan Živadinović, Myra Spiliopoulou   +2 more
doaj   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

An Adaptive Feature-Based Quantum Genetic Algorithm for Dimension Reduction with Applications in Outlier Detection

Algorithms
Dimensionality reduction is essential in machine learning, reducing dataset dimensions while enhancing classification performance. Feature Selection, a key subset of dimensionality reduction, identifies the most relevant features. Genetic Algorithms (GA)
Tin H. Pham, Bijan Raahemi
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Pre Hoc and Co Hoc Explainability: Frameworks for Integrating Interpretability into Machine Learning Training for Enhanced Transparency and Performance

Applied Sciences
Post hoc explanations for black-box machine learning models have been criticized for potentially inaccurate surrogate models and computational burden at prediction time.
Cagla Acun, Olfa Nasraoui
doaj   +1 more source

Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly

Biology Open, 2017
Cardiac development in vertebrates is a finely tuned process regulated by a set of conserved signaling pathways. Perturbations of these processes are often associated with congenital cardiac malformations.
Suzan El-Rass, Shahram Eisa-Beygi, Edbert Khong, Koroboshka Brand-Arzamendi, Antonio Mauro, Haibo Zhang, Karl J. Clark, Stephen C. Ekker, Xiao-Yan Wen   +8 more
doaj   +1 more source