Results 91 to 100 of about 7,291,916 (317)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Big Earth Data, 2018 GeoLink has leveraged linked data principles to create a dataset that allows users to seamlessly query and reason over some of the most prominent geoscience metadata repositories in the United States. The GeoLink dataset includes such diverse information
Michelle Cheatham +8 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Investigating the Challenges and Prospects of Construction Models for Dynamic Knowledge Graphs
IEEE AccessRecently, Dynamic knowledge graphs (DKGs) have been considered the foundation stone for several powerful knowledge-aware applications. DKG has a great advancement over static knowledge graph with the ability to capture the dynamicity of knowledge.
Maha Farghaly +3 more
doaj +1 more source
Key technologies and research progress of medical knowledge graph construction
大数据, 2021 With the continuous iterative updating of Internet technology, the semantic understanding of massive data is becoming more and more important.Knowledge graph is a kind of semantic network that reveals the relationship between entities.Medicine is one of ...
Ling TAN +10 more
doaj
Knowledge Graph Reasoning Based on Textual and Multi-perspective Local Structural Features [PDF]
Jisuanji gongchengIn recent years, knowledge graphs have gradually become the cornerstone of downstream tasks such as question answering, information retrieval, and recommendation systems.
LIU Hai, SHI Fobo, ZHANG Zhaoli, HE Jiawen, LI Jiahao
doaj +1 more source
FEBS Open Bio, EarlyView.Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti +8 more
wiley +1 more source
$R^3$-NL2GQL: A Model Coordination and Knowledge Graph Alignment Approach for NL2GQL [PDF]
, 2023 Yuhang Zhou +9 more
openalex +1 more source