Results 131 to 140 of about 7,092,434 (358)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Semantic-Enhanced Knowledge Graph Completion
MathematicsKnowledge graphs (KGs) serve as structured representations of knowledge, comprising entities and relations. KGs are inherently incomplete, sparse, and have a strong need for completion.
Xu Yuan +6 more
doaj +1 more source
Open-World Knowledge Graph Completion
, 2017 Knowledge Graphs (KGs) have been applied to many tasks including Web search, link prediction, recommendation, natural language processing, and entity linking. However, most KGs are far from complete and are growing at a rapid pace.
Shi, Baoxu, Weninger, Tim
core +1 more source
25 years development of knowledge graph theory: the results and the challenge [PDF]
, 2008 The project on knowledge graph theory was begun in 1982. At the initial stage, the goal was to use graphs to represent knowledge in the form of an expert system.
Hoede, Cornelis, Nurdiati, Sri
core +2 more sources
EventKG: A Multilingual Event-Centric Temporal Knowledge Graph
, 2018 One of the key requirements to facilitate semantic analytics of information regarding contemporary and historical events on the Web, in the news and in social media is the availability of reference knowledge repositories containing comprehensive ...
Demidova, Elena, Gottschalk, Simon
core +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Knowledge Graph Essentials and Key Technologies
Современные информационные технологии и IT-образование, 2019 In recent decades, the amount of information that humankind has accumulated has increased tremendously. People cannot analyze it effectively using simple algorithms, and data structures due to these approaches do not understand the se¬mantics of the data.
Vladislav Gurin +5 more
doaj +1 more source
Convolutional 2D Knowledge Graph Embeddings
, 2018 Link prediction for knowledge graphs is the task of predicting missing relationships between entities. Previous work on link prediction has focused on shallow, fast models which can scale to large knowledge graphs.
Dettmers, Tim +3 more
core +1 more source
NetLSD: Hearing the Shape of a Graph
, 2018 Comparison among graphs is ubiquitous in graph analytics. However, it is a hard task in terms of the expressiveness of the employed similarity measure and the efficiency of its computation.
Bronstein, Alex +4 more
core +1 more source