Results 231 to 240 of about 353,222 (280)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Transforming oncology clinical trial matching through neuro-symbolic, multi-agent AI and an oncology-specific knowledge graph: a prospective evaluation in 3804 patients. [PDF]

ESMO Real World Data Digit Oncol
Loaiza-Bonilla A, Yost C, Kurnaz S, Tuysuz E, Thaker NG, Giritlioglu D, Noel Meza JP.   +6 more
europepmc   +1 more source

A Crack‐Based One‐Dimensional Microspheres Array Enables Thermal–Mechanical Decoupled Dual‐Functional Sensing

Advanced Science, EarlyView.
Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu, Hongyi Tu, Zehao Wang, Tianyu Zhu, Chao Wang, Min Chen, Lan Shi, Limin Wu   +7 more
wiley   +1 more source

A retrospective observational study of characteristics and outcomes of older patients referred to a hospital-based social prescribing programme. [PDF]

Front Public Health
McGowan B, Romero-Ortuno R, Brennan L, Murphy E, Boyle G, Robinson D.   +5 more
europepmc   +1 more source

Memristive Physical Reservoir Computing

Advanced Science, EarlyView.
Memristors’ nonlinear dynamics and input‐dependent memory effects make them ideal candidates for high‐performance physical reservoir computing (RC). Based on their conductance modulation, memristors can be classified as electronic or optoelectronic types.
Dian Jiao, Ziyuan Wang, Jingrui Wang, Li Zhang, Xianhua Wei, Lingxiang Hu, Zongxiao Li, Athanasios V. Vasilakos, Zhizhen Ye, Fei Zhuge   +9 more
wiley   +1 more source

Robot End-Effectors Adaptive Design Method Based on Embedding Domain Knowledge into Reinforcement Learning. [PDF]

Sensors (Basel)
Zhu Y, Zhang T, Lu Y, Yao L.
europepmc   +1 more source

Knowledge graph-based intelligent data management and information innovation service model for university library systems. [PDF]

PLoS One
Liu F.
europepmc   +1 more source

Causal knowledge graph analysis identifies adverse drug effects. [PDF]

Bioinformatics
Toonsi S, Schofield PN, Hoehndorf R.
europepmc   +1 more source

MELGene: knowledge-enhanced multimodel ensemble learning for disease-gene association prediction. [PDF]

Brief Bioinform
Tian H, Yang K, Liu Z, Gao H, Yu J, Zhang L, Zhou X.   +6 more
europepmc   +1 more source

Seeing through the virtual reality: the effects of learning environment and task difficulty on difficulty perception, learning outcomes and mental models. [PDF]

Front Psychol
Shan M, Du S, Shangguan C, Li M.
europepmc   +1 more source