Results 131 to 140 of about 8,049,750 (250)

Music recommendation algorithms based on knowledge graph and multi-task feature learning

Scientific Reports
During music recommendation scenarios, sparsity and cold start problems are inevitable. Auxiliary information has been utilized in music recommendation algorithms to provide users with more accurate music recommendation results.
Xinqiao Liu, Zhisheng Yang, Jinyong Cheng   +2 more
doaj   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Ensembles of knowledge graph embedding models improve predictions for drug discovery. [PDF]

Brief Bioinform, 2022
Rivas-Barragan D, Domingo-Fernández D, Gadiya Y, Healey D.   +3 more
europepmc   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source

Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding. [PDF]

Sci Rep, 2023
Islam MK, Amaya-Ramirez D, Maigret B, Devignes MD, Aridhi S, Smaïl-Tabbone M.   +5 more
europepmc   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Multimodal reasoning based on knowledge graph embedding for specific diseases. [PDF]

Bioinformatics, 2022
Zhu C, Yang Z, Xia X, Li N, Zhong F, Liu L.   +5 more
europepmc   +1 more source

Static detection method for multi-level network source code vulnerabilities based on knowledge graph technology

Discover Artificial Intelligence
The current static detection method of network source code vulnerabilities mainly relies on the static analysis of binary code. However, due to the failure to fully simulate the actual operating environment of programs, some vulnerabilities that trigger ...
Peng Xiao, Lina Zhang, Ying Yan, Zhenhong Zhang   +3 more
doaj   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

MedGraph: A semantic biomedical information retrieval framework using knowledge graph embedding for PubMed. [PDF]

Front Big Data, 2022
Ebeid IA.
europepmc   +1 more source