Results 161 to 170 of about 30,563 (303)

Knowledge graph embedding for profiling the interaction between transcription factors and their target genes. [PDF]

PLoS Comput Biol, 2023
Wu YH, Huang YA, Li JQ, You ZH, Hu PW, Hu L, Leung VCM, Du ZH.   +7 more
europepmc   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Predicting protein and pathway associations for understudied dark kinases using pattern-constrained knowledge graph embedding. [PDF]

PeerJ, 2023
Salcedo MV, Gravel N, Keshavarzi A, Huang LC, Kochut KJ, Kannan N.   +5 more
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Combining the External Medical Knowledge Graph Embedding to Improve the Performance of Syndrome Differentiation Model. [PDF]

Evid Based Complement Alternat Med, 2023
Ye Q, Yang R, Cheng CL, Peng L, Lan Y.
europepmc   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Static detection method for multi-level network source code vulnerabilities based on knowledge graph technology

Discover Artificial Intelligence
The current static detection method of network source code vulnerabilities mainly relies on the static analysis of binary code. However, due to the failure to fully simulate the actual operating environment of programs, some vulnerabilities that trigger ...
Peng Xiao, Lina Zhang, Ying Yan, Zhenhong Zhang   +3 more
doaj   +1 more source

Ensembles of knowledge graph embedding models improve predictions for drug discovery. [PDF]

Brief Bioinform, 2022
Rivas-Barragan D, Domingo-Fernández D, Gadiya Y, Healey D.   +3 more
europepmc   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding. [PDF]

Sci Rep, 2023
Islam MK, Amaya-Ramirez D, Maigret B, Devignes MD, Aridhi S, Smaïl-Tabbone M.   +5 more
europepmc   +1 more source