Results 41 to 50 of about 8,049,750 (250)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Statistics of datasets used for training and evaluating the knowledge graph embedding models.

, 2021
Statistics of datasets used for training and evaluating the knowledge graph embedding models.
Wonjun Choi (1439263), Hyunju Lee (51046)   +1 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Improving FMEA Comprehensibility via Common-Sense Knowledge Graph Completion Techniques

IEEE Access, 2023
The Failure Mode Effect Analysis process (FMEA) is widely used in industry for risk assessment, as it effectively captures and documents domain-specific knowledge. This process is mainly concerned with causal domain knowledge.
Houssam Razouk, Xing Lan Liu, Roman Kern
doaj   +1 more source

Knowledge Graph Embedding for Ecotoxicological Effect Prediction [PDF]

, 2019
Exploring the effects a chemical compound has on a species takes a considerable experimental effort. Appropriate methods for estimating and suggesting new effects can dramatically reduce the work needed to be done by a laboratory.
Jimenez-Ruiz, E., Hartig, Olaf, Tollefsen, Knut-Erik, Gandon, Fabien, Maleshkova, Maria,, Lefrançois, Maxime,, Svátek, Vojtěch,, On,, Myklebust, Erik Bryhn, Cruz, Isabel,, Svatek, Vojtech, Hartig, Olaf,, Wolf, R., Cruz, Isabel F., Gandon, Fabien,, Myklebust, E., Jimenez-Ruiz, Ernesto, Tollefsen, K. E., Song, Jie, Hogan, Aidan, Maleshkova, Maria, Cruz, Isabel, G, Fabien, Lefrançois, Maxime, Aidan, Hogan, Ghidini, Chiara,, Chen, J., Song, Jie,, Ghidini, Chiara, Wolf, Raoul, Hogan, Aidan,, Chen, Jiaoyan, Chiara Veninata, Maleshkova, Maria.editor.(orcid)0000-0003-3458-4748https://orcid.org/0000-0003-3458-4748edthttp://id.loc.gov/vocabulary/relators/edt, Aldo Gangemi, Song, Jie.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Andrea Giovanni Nuzzolese, Lefrançois, Maxime.editor.(orcid)0000-0001-9814-8991https://orcid.org/0000-0001-9814-8991edthttp://id.loc.gov/vocabulary/relators/edt, Hogan, Aidan.editor.(orcid)0000-0001-9482-1982https://orcid.org/0000-0001-9482-1982edthttp://id.loc.gov/vocabulary/relators/edt, Ghidini, Chiara.editor.(orcid)0000-0003-1563-4965https://orcid.org/0000-0003-1563-4965edthttp://id.loc.gov/vocabulary/relators/edt, Valentina Anita Carriero, Valentina Presutti, Ludovica Marinucci, SpringerLink (Online service), Svátek, Vojtěch.editor.(orcid)0000-0002-2256-2982https://orcid.org/0000-0002-2256-2982edthttp://id.loc.gov/vocabulary/relators/edt, Gandon, Fabien.editor.(orcid)0000-0003-0543-1232https://orcid.org/0000-0003-0543-1232edthttp://id.loc.gov/vocabulary/relators/edt, Cruz, Isabel.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Hartig, Olaf.editor.(orcid)0000-0002-1741-2090https://orcid.org/0000-0002-1741-2090edthttp://id.loc.gov/vocabulary/relators/edt, Maria Letizia Mancinelli   +48 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Restricting the Spurious Growth of Knowledge Graphs by Using Ontology Graphs

IEEE Access
Knowledge Graphs have demonstrated a real advantage in knowledge representation, leveraging graphs NoSQL structures and schema-less technology, which offers superior comprehension, knowledge representation, interpretation, and reasoning.
Kina Tatchukova, Yanzhen Qu
doaj   +1 more source

Predicting biomedical relationships using the knowledge and graph embedding cascade model.

PLoS ONE, 2019
Advances in machine learning and deep learning methods, together with the increasing availability of large-scale pharmacological, genomic, and chemical datasets, have created opportunities for identifying potentially useful relationships within ...
Xiaomin Liang, Daifeng Li, Min Song, Andrew Madden, Ying Ding, Yi Bu   +5 more
doaj   +1 more source

The impact of four different training methods for knowledge graph embedding (NDCG@5).

, 2022
The impact of four different training methods for knowledge graph embedding (NDCG@5).
Weiqiang Di (12936582), Youfang Lin (514371), ZhiHao Wu (12936585)   +2 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source