Results 31 to 40 of about 1,026,860 (260)
Heliyon, 2023 Standardized routine operation management (SROM) has been widely accepted and applied by kinds of enterprises and played a key supporting role. With full use of the emerging knowledge-based smart management technology, SROM will further increase ...
Peihan Wen, Yiming Zhao, Jin Liu
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
OpenBiodiv: A Knowledge Graph for Literature-Extracted Linked Open Data in Biodiversity Science
Publications, 2019 Hundreds of years of biodiversity research have resulted in the accumulation of a substantial pool of communal knowledge; however, most of it is stored in silos isolated from each other, such as published articles or monographs.
Lyubomir Penev +6 more
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TOWARDS THE INTEGRATION OF QUALITY MANAGEMENT SYSTEMS AND KNOWLEDGE MANAGEMENT SYSTEM IN HIGHER EDUCATION INSTITUTION: DEVELOPMENT OF Q-EDGE KMS MODEL [PDF]
Acta Informatica Malaysia, 2018 Quality management system (QMS) and knowledge management system (KMS) are two management discipline that are widely used in organizations. The implementation and adoption of QMS is a continuous effort that helps organizations to improve their quality and
Mohammad Fakhrulnizam +4 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Health Research Policy and SystemsBackground The WHO Regional Office for Africa reviewed evidence-based interventions designed to enhance health systems outputs: access, quality, demand and resilience.
Humphrey Cyprian Karamagi +10 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
An Integrated Knowledge Management System [PDF]
Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2014 The aim of this paper is to present a Knowledge Management System based on Fuzzy Logic (FLKMS), a real-time expert system to meet the challenges of the dynamic environment.
Vasile Mazilescu
doaj
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source