Results 111 to 120 of about 5,283,414 (302)

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Developing and evaluating a lay health worker delivered implementation intervention to decrease engagement disparities in behavioural parent training: a mixed methods study protocol. [PDF]

, 2019
IntroductionBehavioural parent training (BPT) programmes are effective in preventing and treating early-onset conduct problems and child maltreatment. Unfortunately, pervasive mental health service disparities continue to limit access to and engagement ...
Barnett, Miya, Kia-Keating, Maryam, Landsverk, John, Lau, Anna S, Miranda, Jeanne, Saldana, Lisa   +5 more
core   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, EarlyView.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Bridging the World of Philanthropy: Present and Future [PDF]

, 2012
This paper was inspired by discussions from two events convened as part of the Bellagio Initiative on the Future of Philanthropy and DevelopmentThe Forum on Bridging Philanthropy and Development in Africa and Asia took place in June 2012.

core  

Knowledge Mobilisation Capacity Building Workshop

, 2021
A workshop aimed at building skills in systems thinking and knowledge mobilisation practices to effectively establish a knowledge pathway for their own research. Traditionally, efforts by researchers to inform policy and practice would focus on the publication and dissemination of research findings.
openaire   +1 more source

Using developmental evaluation principles to build capacity for knowledge mobilisation in health and social care

Evaluation, 2019
This article contributes to Developmental Evaluation practice by highlighting the impact of embedding Developmental Evaluation principles into the learning approach of a capacity building initiative named Evidence for Change.
Lesley M. Harper, R. Dickson
semanticscholar   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Citizen Engagement for Social and Technological Innovation in Sustainable Energy Systems

Advanced Energy and Sustainability Research, EarlyView.
This study underscores the potential of citizen participation in the energy transition by providing insights to foster citizen‐driven innovation. An analysis of energy communities, one of the most dynamic innovations in the energy sector, reveals that these models can be citizen‐led initiatives regarding their operational and organizational structure ...
Ana Belén Cristóbal, Cristina Sanz‐Cuadrado, Kiane Alves e Silva, Luis Narvarte   +3 more
wiley   +1 more source

Research utilisation and knowledge mobilisation in the commissioning and joint planning of public health interventions to reduce alcohol-related harms: a qualitative case design using a cocreation approach

Health Services and Delivery Research, 2015
Background: Considerable resources are spent on research to establish what works to improve the nation’s health. If the findings from this research are used, better health outcomes can follow, but we know that these findings are not always used.
Rosemary K Rushmer, Mandy Cheetham, Lynda Cox, Ann Crosland, Joanne Gray, Liam Hughes, David J Hunter, Karen McCabe, Pete Seaman, Carol Tannahill, Peter Van Der Graaf   +10 more
doaj   +1 more source