Results 41 to 50 of about 148,575 (264)

A Supramolecular Ferroelectric With Two Sublattices and Polarization Dependent Conductivity

Advanced Science, EarlyView.
Ferroelectric behavior in a supramolecular material with two, independently switchable, sublattices is demonstrated. The sublattices can be associated with the two dipolar groups in the compound. Moreover, the polarization is found to couple to the charge transport in the material, giving rise to a switchable, directional conductivity.
H. Mager, M. Litterst, Sophia Klubertz, Shyamkumar V. Haridas, Oleksandr Shyshov, M. von Delius, M. Kemerink   +6 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Field investigation of deformation characteristics and stress mobilisation of a soil slope [PDF]

, 2015
Stress mobilisation and deformation of a slope are important for engineers to carry out reliable design of retaining systems. However, most case histories reported mainly on the response of pore-water pressure (PWP), whereas knowledge about the stress ...
AK Leung, AK Leung, AK Leung, Anthony Kwan Leung, BSI, Charles Wang Wai Ng, CWW Ng, CWW Ng, CWW Ng, CWW Ng, CWW Ng, I Meilani, IJA Brackley, JA Smethurst, JD Coleman, K Sassa, MT Genuchten Van, N Khalili, SMO, T Sakaki, TT Lim, WA Take, YK Kim   +22 more
core   +3 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

System implementation: managing project and post project stage - case study in an Indonesian company [PDF]

, 2007
The research reported in this paper aims to get a better\ud understanding of how the implementation process of\ud enterprise systems (ES) can be managed, by studying the\ud process from an organisational perspective.
Bruijn, Erik Joost de, Fisscher, Olaf M., Govindaraju, Rajesri   +2 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Bridging the World of Philanthropy: Present and Future [PDF]

, 2012
This paper was inspired by discussions from two events convened as part of the Bellagio Initiative on the Future of Philanthropy and DevelopmentThe Forum on Bridging Philanthropy and Development in Africa and Asia took place in June 2012.

core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

The obligatory passage point : abstracting the meaning in tacit knowledge [PDF]

, 2013
The lived experience of individuals in the workplace results in an accumulation of dispositions to act. Such dispositions have been termed knowledge [Boisot 1998]. Further, this knowledge is considered to be tacit or explicit [Baumard 1999].
Walton, John
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