Results 61 to 70 of about 5,283,414 (302)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Foreword [PDF]

, 2018
No abstract ...
Lennox, Corinne, Waites, Matthew
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Expert consensus for respiratory physiotherapy management of mechanically ventilated adults with community-acquired pneumonia: A Delphi study [PDF]

, 2018
Rationale and aims: Patients with community‐acquired pneumonia (CAP) are frequently admitted to an intensive care unit. Physiotherapy may be provided to optimize respiratory function; however, there is significant variability in clinical practice and ...
Braun V, Dennis D, Hodgson C, Hsu CC, McMillan SS, Portney LG   +5 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021

Arthritis Care &Research, EarlyView.
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site‐specific OA across 204 countries and territories were obtained from the Global Burden of Diseases, Injuries, and ...
Haowei Chen, Lei Si, David J. Hunter, Lei Zhang, Zhe‐Sheng Chen, Xiaomeng Wang, Vicky Duong, Zhounan Zhou, Peihua Cao, Han Cen, Su'an Tang, Tianyu Chen, Houjun Xue, Zhaohua Zhu, Changhai Ding   +14 more
wiley   +1 more source

Older adults’ lived experiences of caring relationships with home care nurses – being in an in-between restricted or enabled existential freedom

International Journal of Qualitative Studies on Health & Well-Being
Purpose The aim of this study is to describe the essential meaning of the phenomenon of caring relationships in home care for older adults in Denmark, based on their lived experiences of caring relationships with home care nurses.
Karoline Lang Mathiesen, Elisabeth Lindberg, Kristina Nässén, Fiona Cowdell, Lina Palmér   +4 more
doaj   +1 more source

Developing and implementing an integrated delirium prevention system of care:a theory driven, participatory research study [PDF]

, 2013
Background: Delirium is a common complication for older people in hospital. Evidence suggests that delirium incidence in hospital may be reduced by about a third through a multi-component intervention targeted at known modifiable risk factors.
A Edlund, A McIntyre, AE Powell, C May, C May, CV Lukas, DK Kiely, DL Fixsen, DL Leslie, DL Leslie, E Marcantonio, EH Bradley, EM Eeles, ER Marcantonio, ER Marcantonio, ER Marcantonio, FH Rubin, Francine Cheater, GK SteelFisher, GS Duppils, HC Kaplan, J Corbin, J Day, J McCusker, J Ovretveit, J Witlox, JA Rizzo, Jane Smith, John B Young, John Green, K Milisen, K Milisen, KH Pitkala, LJ Damschroder, LJ Young, Mary Godfrey, MG Cole, P Bate, P Galanakis, P Hawe, P Hawe, P Pronovost, P Williams-Russo, R Grol, Royal College of Psychiatrists, S Dahlke, Sharon K Inouye, SK Inouye, SK Inouye, SK Inouye, SK Inouye, SK Inouye, ST O'Keeffe, T Greenhalgh, Y Gustafson   +54 more
core   +1 more source

Making authentic: exploring boundary objects and bricolage in knowledge mobilisation through National Health Service-university partnerships

, 2020
Background: In healthcare, bridging the research-to-practice gap is a top priority. Knowledge mobilisation scholars suggest that this gap can be closed through collaboration between knowledge users and producers.
Lucy Melville-Richards, J. Rycroft-Malone, C. Burton, Joyce E. Wilkinson   +3 more
semanticscholar   +1 more source