Results 111 to 120 of about 1,523,414 (311)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Non-linear effects in knowledge production [PDF]
The generation of technological knowledge is paramount to our present development. Economic science concentrates on representing the functions of production applied to all sectors, e.g., the well known Cobb-Douglas model, associated with parameters such ...
Purica, Ionut
core
Capability accumulation patterns across economic, innovation, and knowledge-production activities. [PDF]
Sci Rep, 2023 Patelli A +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The complex interaction between Global Production Networks, Digital Information Systems and International Knowledge Transfers [PDF]
Traditionally many studies of knowledge in economics have focused on localized networks and intra-regional collaborations. However, the rising frequency by which firms collaborate within the context of global networks of production and innovation, the ...
Dieter Ernst +2 more
core
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
The Impact of R&D Offshoring on the Home Knowledge Production of OECD Investing Regions [PDF]
This paper investigates the relationship between home and offshore R&D activities on the knowledge production of the investing home region. Debate is ongoing on whether R&D offshoring complements the R&D performed at home.
Keld Laursen +2 more
core
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
The Internationalisation of R&D and the Knowledge Production Function [PDF]
This paper considers the effect of acquisition FDI on the knowledge production function. We distinguish between acquisitions by MNEs from technologically leading countries and those behind the technological frontier. We show that both acquire similarly R&
María García-Vega +2 more
core
Our economy has changed from an industrial into a knowledge economy in which knowledge productivity has become the main challenge. The lack of appropriate techniques to reveal knowledge productivity hinders organizations to design effective policies aiming at improving knowledge-based performance. The objective of this research is to develop and test a
openaire +1 more source