Results 171 to 180 of about 9,552,944 (333)

PToPI: A Comprehensive Review, Analysis, and Knowledge Representation of Binary Classification Performance Measures/Metrics. [PDF]

SN Comput Sci, 2023
Canbek G, Taskaya Temizel T, Sagiroglu S.   +2 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Knowledge Representation and Management: Interest in New Solutions for Ontology Curation. [PDF]

Yearb Med Inform, 2021
Dhombres F, Charlet J, Section Editors for the IMIA Yearbook Section on Knowledge Representation and Management.   +2 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Sickle Cell Disease Ontology: recent development and expansion of the universal sickle cell knowledge representation. [PDF]

Database (Oxford), 2022
Mazandu GK, Hotchkiss J, Nembaware V, Wonkam A, Mulder N.   +4 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Knowledge Representation for Multi-Scale Physiology Route Modeling. [PDF]

Front Neuroinform, 2021
Kokash N, de Bono B.
europepmc   +1 more source

Propositional Knowledge Representation and Reasoning in Restricted Boltzmann Machines [PDF]

, 2017
Son N. Tran
openalex   +1 more source

Artificial Intelligence in Medicine: Knowledge Representation and Transparent and Explainable Systems: AIME 2019 International Workshops, KR4HC/ProHealth and TEAAM, Poznan, Poland, June 26–29, 2019, Revised Selected Papers

KR4HC/ProHealth/TEAAM@AIME, 2019
Mar Marcos, Jose M. Juarez, Richard Lenz, G. J. Nalepa, Slawomir Nowaczyk, M. Peleg, Jerzy Stefanowski, Gregor Stiglic   +7 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source