Results 221 to 230 of about 6,753,811 (352)

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Emotional distress and affective knowledge representation one year after the COVID-19 outbreak. [PDF]

PLoS One
Barca L, Iodice P, Chaigneau A, Lancia G, Pezzulo G.   +4 more
europepmc   +1 more source

Ontologies, Knowledge Representation, and Machine Learning for Translational Research: Recent Contributions. [PDF]

Yearb Med Inform, 2020
Robinson PN, Haendel MA.
europepmc   +1 more source

Knowledge representation issues in default reasoning

, 1990
J. Terry Nutter
openalex   +2 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Knowledge Representation and Management: 2023 Highlights and the Rise of Knowledge Graph Embeddings. [PDF]

Yearb Med Inform
Charlet J, Cui L, Section Editors for the IMIA Yearbook Section on Knowledge Representation and Management.   +2 more
europepmc   +1 more source

Semantic Knowledge Representation for Strategic Interactions in Dynamic Situations. [PDF]

Front Neurorobot, 2020
Calvo Tapia C, Villacorta-Atienza JA, Díez-Hermano S, Khoruzhko M, Lobov S, Potapov I, Sánchez-Jiménez A, Makarov VA.   +7 more
europepmc   +1 more source

Knowledge Representation for Lexical Semantics: Is Standard First Order Logic Enough?

, 1994
Marc Light, Lenhart K. Schubert
openalex   +2 more sources

Why Base the Knowledge Representation Language on Natural Language? [PDF]

, 2000
Fernando Gómez
openalex   +1 more source