Results 61 to 70 of about 718,276 (317)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Research on Traditional Chinese Medicine: Domain Knowledge Graph Completion and Quality Evaluation
JMIR Medical InformaticsBackgroundKnowledge graphs (KGs) can integrate domain knowledge into a traditional Chinese medicine (TCM) intelligent syndrome differentiation model. However, the quality of current KGs in the TCM domain varies greatly, related to
Chang Liu +7 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Knowledge Representation and Reasoning for Intelligent Software Systems [PDF]
Computer, 2011 non-peer ...
Vassev E., Hinchey M.
openaire +1 more source
A Semantic Approach for Building System Operations: Knowledge Representation and Reasoning [PDF]
, 2022 Parastoo Delgoshaei +2 more
openalex +1 more source
DESIGNING OBJECT-ORIENTED REPRESENTATIONS FOR REASONING FROM FIRST-PRINCIPLES [PDF]
, 1991 Modeling expert knowledge using "situation-action" rules is not always feasible in knowledge intensive domains involving volatile knowledge (e.g., trading).
Benaroch, Michel
core
Asynchronous Multi-Context Systems
, 2015 In this work, we present asynchronous multi-context systems (aMCSs), which provide a framework for loosely coupling different knowledge representation formalisms that allows for online reasoning in a dynamic environment. Systems of this kind may interact
G. Brewka, J. Lang, J.J. Alferes
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
BMC Medical Informatics and Decision Making, 2021 Background Knowledge graphs (KGs), especially medical knowledge graphs, are often significantly incomplete, so it necessitating a demand for medical knowledge graph completion (MedKGC). MedKGC can find new facts based on the existed knowledge in the KGs.
Yinyu Lan +5 more
doaj +1 more source