Results 71 to 80 of about 737,979 (348)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Research on Traditional Chinese Medicine: Domain Knowledge Graph Completion and Quality Evaluation
JMIR Medical InformaticsBackgroundKnowledge graphs (KGs) can integrate domain knowledge into a traditional Chinese medicine (TCM) intelligent syndrome differentiation model. However, the quality of current KGs in the TCM domain varies greatly, related to
Chang Liu +7 more
doaj +1 more source
Information, knowledge and the context of interaction [PDF]
, 2008 Representing knowledge as information content alone is insufficient in providing us with an understanding of the world around us. A combination of context as well as reasoning of the information content is fundamental to representing knowledge, within ...
Sharif, A M
core
Asynchronous Multi-Context Systems
, 2015 In this work, we present asynchronous multi-context systems (aMCSs), which provide a framework for loosely coupling different knowledge representation formalisms that allows for online reasoning in a dynamic environment. Systems of this kind may interact
G. Brewka, J. Lang, J.J. Alferes
core +1 more source
Knowledge Representation and Reasoning for Intelligent Software Systems [PDF]
Computer, 2011 non-peer ...
Vassev E., Hinchey M.
openaire +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
BMC Medical Informatics and Decision Making, 2021 Background Knowledge graphs (KGs), especially medical knowledge graphs, are often significantly incomplete, so it necessitating a demand for medical knowledge graph completion (MedKGC). MedKGC can find new facts based on the existed knowledge in the KGs.
Yinyu Lan +5 more
doaj +1 more source
A knowledge based software engineering environment testbed [PDF]
, 1985 The Carnegie Group Incorporated and Boeing Computer Services Company are developing a testbed which will provide a framework for integrating conventional software engineering tools with Artifical Intelligence (AI) tools to promote automation and ...
Baker, L., Gill, C., Reedy, A.
core +1 more source