Results 81 to 90 of about 737,979 (348)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

DESIGNING OBJECT-ORIENTED REPRESENTATIONS FOR REASONING FROM FIRST-PRINCIPLES [PDF]

open access: yes, 1991
Modeling expert knowledge using "situation-action" rules is not always feasible in knowledge intensive domains involving volatile knowledge (e.g., trading).
Benaroch, Michel
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Model the System from Adversary Viewpoint: Threats Identification and Modeling

open access: yes, 2014
Security attacks are hard to understand, often expressed with unfriendly and limited details, making it difficult for security experts and for security analysts to create intelligible security specifications.
Apvrille, Ludovic   +2 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

The response of soil microbial community to application of organic amendment to saline land

open access: yesFrontiers in Microbiology
IntroductionThe salinization of coastal soils is a primary cause of global land degradation. The aim of this study was to evaluate the effect of organic amendment on the soil microbial community within a saline gradient.MethodsThe study was designed with
Peifei Cong   +7 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Integration of a case-based reasoning and an ontological know ledge base in the system of intelligent support of finite element analysis

open access: yesComputer Assisted Methods in Engineering and Science, 2022
The process of engineering analysis, especially its preprocessing stage, comprises some knowledge-based tasks which influence the quality of the results greatly, require considerable level of expertise from an engineer; the support for these tasks by ...
Peter Wriggers   +4 more
doaj  

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