Results 151 to 160 of about 13,515,394 (353)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Knowledge Management and Sustainable Agriculture:the Italian Case [PDF]

, 2017
The contemporary knowledge-based economy requires global usage of information in all aspects of modern society. Pertinent information is an important asset for successful business, therefore an application of knowledge management in organisational ...
Zecca, F.
core  

Physiotherapists Lack Knowledge in Mental Health: A Survey of Knowledge and Attitudes of Physical Therapists About Their Role in Mental Health

Journal of Multidisciplinary Healthcare
Madawi Alotaibi,1 Alanoud Alotaibi,1 Amani Alqahtani,1 Rand Alghonaim,1 Samira Alzahrani,1 Tala Altamimi,1 Doaa Aljasser,2 Samiah Alqabbani,1 Afrah Almuwais1 1Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess ...
Alotaibi M, Alotaibi A, Alqahtani A, Alghonaim R, Alzahrani S, Altamimi T, Aljasser D, Alqabbani S, Almuwais A   +8 more
doaj  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Contextualism and Knowledge Norms [PDF]

, 2017
I provide an opinionated overview of the literature on the relationship of contextualism to knowledge norms for action, assertion, and belief. I point out that contextualists about ‘knows’ are precluded from accepting the simplest versions of knowledge ...
Worsnip, Alex
core  

Sarcopenia knowledge of geriatric rehabilitation patients is low while they are willing to start sarcopenia treatment: EMPOWER‐GR

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia is prevalent in 20–50% of geriatric rehabilitation inpatients and is associated with functional dependence and mortality. The aim is to assess knowledge of geriatric rehabilitation inpatients on sarcopenia and their willingness and ...
Laure M.G. Verstraeten, Amir Mashni, Janneke P. vanWijngaarden, Carel G.M. Meskers, Andrea B. Maier   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Latinos and the 2010 Census: The Foreign Born Are More Positive [PDF]

, 2010
Compares survey results on knowledge of, attitudes toward, and participation in the census among foreign- and U.S.-born Latinos/Hispanics and Spanish-speaking, bilingual, and English-speaking Latinos/Hispanics.
Mark Hugo Lopez, Paul Taylor
core  

Survey of Relationship between Knowledge Management Processes and Knowledge Management Effectiveness [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2005
In this research at first knowledge management processes and knowledge management effectiveness are surveyed witch use of confirmatory factor analysis then knowledge management processes (from Nonaka's perspective: internalization, externalization ...
Gholamreza Khoshsima, Mehdi Ebrahiminejad, Hamidreza Fallah Lajimi   +2 more
doaj