Results 61 to 70 of about 3,259,897 (297)

Searching for effective and efficient way of knowledge transfer within an organization

open access: yes, 2017
In this paper three models of knowledge transfer in organization are considered. In the first model (A) the transfer of chunks of knowledge among agents is possible only when the sender has exactly one more chunks of knowledge than recipient. This is not
Kowalska-Styczeń, Agnieszka   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Initial teacher education 2024: why inclusion matters? [PDF]

open access: yesQuality Education for All
– Teacher recruitment is under pressure across England with the majority of routes into teaching facing challenges in respect to recruitment and retention. Schools are also challenged by issues of attendance, behaviour and exclusion. This paper examines
Sonia Blandford
doaj   +1 more source

Exploring the evidence base : an overview of the literature on the economic impact of knowledge transfer [PDF]

open access: yes, 2008
This paper presents a policy-focused overview of relevant extant and ongoing research relating to the economic impact of knowledge transfer from higher education institutions.
Kelly, Ursula
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Training Research Skills for High School Students in Vietnam: A Case Study

open access: yesVietnam Journal of Education
This article presents a case study in Vietnam where a course on research skills was taught to outstanding high school students who are preparing to study abroad.
Hiep-Hung Pham, Linh-Chi Nguyen
doaj   +1 more source

The profile of a professional reader: Ivo Vojnović’s reading practices

open access: yesLibellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012
The aim of the paper is to reconstruct the reading profile of Ivo Vojnović using the literature overview and the analysis of his personal correspondence, in order to answer the research questions suggested in Robert Darnton’s methodological texts.
Nada Topić
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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